Evaluation of itch and pain induced by bovine adrenal medulla (BAM)8–22, a new human model of non-histaminergic itch
| Autor: | Giulia Erica Aliotta, Silvia Lo Vecchio, Jesper Elberling, Lars Arendt‐Nielsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Aliotta, G E, Lo Vecchio, S, Elberling, J & Arendt-Nielsen, L 2022, ' Evaluation of itch and pain induced by bovine adrenal medulla (BAM)8–22, a new human model of non-histaminergic itch ', Experimental Dermatology, vol. 31, no. 9, pp. 1402-1410 . https://doi.org/10.1111/exd.14611 Aliotta, G E, Lo Vecchio, S, Elberling, J & Arendt-Nielsen, L 2022, ' Evaluation of itch and pain induced by bovine adrenal medulla (BAM)8-22, a new human model of non-histaminergic itch ', Experimental Dermatology, vol. 31, no. 9, pp. 1402-1410 . https://doi.org/10.1111/exd.14611 |
| DOI: | 10.1111/exd.14611 |
| Popis: | Chronic itch is a socioeconomic burden with limited management options. Non-histaminergic itch, involved in problematic pathological itch conditions, is transmitted by a subgroup of polymodal C-fibres. Cowhage is traditionally used for studying experimentally induced non-histaminergic itch in humans but encounters some limitations. The present study, therefore, aims to design a new human, experimental model of non-histaminergic itch based on the application of bovine adrenal medulla (BAM)8-22, an endogenous peptide that activates the MrgprX1 receptor. Twenty-two healthy subjects were recruited. Different concentrations (0.5, 1 and 2 mg/ml) of BAM8-22 solution and vehicle, applied by a single skin prick test (SPT), were tested in the first session. In the second session, the BAM8-22 solution (1 mg/ml) was applied by different number of SPTs (1, 5 and 25) and by heat-inactivated cowhage spicules coated with BAM8-22. Provoked itch and pain intensities were monitored for 9 min, followed by the measurement of superficial blood perfusion (SBP) and mechanical and thermal sensitivities. BAM8-22 induced itch at the concentration of 1, 2 mg/ml (p |
| Databáze: | OpenAIRE |
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