Point-of-Care Ultrasound—A New Option for Early Quantitative Assessment of Pulmonary Edema
| Autor: | Xihua Lian, Yongjian Chen, Jingyun Li, Yiming Zeng, Zhirong Xu, Guorong Lv, Weijing Wu, Xiaoshan Su, Liqing Zeng, Zhixing Zhu |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology Acoustics and Ultrasonics Biophysics Pulmonary Edema Severity of Illness Index Random Allocation 03 medical and health sciences 0302 clinical medicine Quantitative assessment Animals Medicine Radiology Nuclear Medicine and imaging Ultrasonography Lung Radiological and Ultrasound Technology business.industry Point of care ultrasound Ultrasound biochemical phenomena metabolism and nutrition respiratory system Pulmonary edema medicine.disease respiratory tract diseases Disease Models Animal Early Diagnosis 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Point-of-Care Testing Histopathology Rabbits business Blood ph Ex vivo |
| Zdroj: | Ultrasound in Medicine & Biology. 46:1-10 |
| ISSN: | 0301-5629 |
| Popis: | The aim of the work described here was to investigate the value of point-of-care ultrasound (POCUS) in the early assessment of the severity of pulmonary edema in rabbits. A rabbit oleic acid (OA)-induced pulmonary edema model was used. Thirty-two New Zealand rabbits were randomly divided into four groups: a control group and three pulmonary edema groups (mild, moderate and severe). Features of transthoracic B-line artifacts (BLA), blood pH, PaO2 and PaCO2, serum inflammatory factors, lung coefficient (LC), lung wet-to-dry weight ratio (W/D) and lung histopathology were assessed. BLA features and severity of pulmonary edema were semiquantitatively scored. Correlations between the number of BLA and PaO2, PaCO2, serum inflammatory factors, LC and W/D were analyzed. An additional 8 rabbits with severe pulmonary edema were used as the verified group, in which the lung was divided into ex vivo BLA (BLA-ev)-free (BLA-ev-free) and BLA-ev-clustered subregions depending on the features of BLA-ev recorded by ex vivo lung ultrasound. Lung specimens from each subregion were collected for histopathological examination. Relationships between features of BLA-ev and lung histopathological abnormalities were analyzed. With increasing doses of OA, number of BLA, W/D and levels of serum inflammatory factors decreased. Meanwhile, lung pathologic abnormalities were aggravated. In addition, time of appearance of BLA, blood pH and PaO2, and PaCO2 decreased dose dependently on OA (p |
| Databáze: | OpenAIRE |
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