Daily intake of heat-killed Lactobacillus plantarum L-137 improves inflammation and lipid metabolism in overweight healthy adults: a randomized-controlled trial

Autor: Tanaka Yusuke, Yasunobu Yoshikai, Yoshihiro Yamamoto, Shinji Murosaki, Yoshitaka Hirose
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: European Journal of Nutrition
ISSN: 1436-6215
1436-6207
Popis: PurposeThe effects of heat-killedLactobacillus plantarumL-137 (HK L-137) on inflammation and lipid metabolism were investigated in overweight volunteers.MethodsOne hundred healthy subjects with a body mass index from 23.0 to 29.9 (51 men and 49 women; mean age: 41.4 years) were enrolled in this randomized, double-blind, placebo-controlled, parallel group study. Subjects were randomly assigned to daily administration of a tablet containing HK L-137 (10 mg) or a placebo tablet for 12 weeks. Blood samples were collected every 4 weeks to measure biomarkers of lipid metabolism and inflammatory mediators.ResultsThe percent change of concanavalin A-induced proliferation of peripheral blood mononuclear cells was significantly larger in the HK L-137 group than in the control group, similar to previous studies. The decreases of aspartate aminotransferase and alanine aminotransferase over time were significantly larger in the HK L-137 group than in the control group, as were the decreases of total cholesterol, low-density lipoprotein cholesterol, and the leukocyte count at one time point. These effects of HK L-137 were stronger in the subjects with higher C-reactive protein levels.ConclusionsThese findings suggest that daily intake of HK L-137 can improve inflammation and lipid metabolism in subjects at risk of inflammation.
Databáze: OpenAIRE
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