Prostate specific antigen in women with menstrual disturbances and fibrocystic mastopathy
| Autor: | S. Radowicki, M. Kunicki |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Fibrocystic Breast Disease Adolescent Endocrinology Diabetes and Metabolism media_common.quotation_subject Fluoroimmunoassay Physiology Thyrotropin urologic and male genital diseases Statistics Nonparametric Endocrinology Sex hormone-binding globulin Sex Hormone-Binding Globulin Medicine Humans Testosterone Prospective Studies Polymenorrhea Prospective cohort study Menstrual cycle Menstrual Cycle Menstruation Disturbances Progesterone media_common Gynecology Analysis of Variance biology Estradiol business.industry Luteinizing Hormone Middle Aged Prostate-Specific Antigen Prolactin Prostate-specific antigen Thyroxine biology.protein Female Follicle Stimulating Hormone business Hormone |
| Zdroj: | Journal of endocrinological investigation. 32(10) |
| ISSN: | 1720-8386 |
| Popis: | The objective of this study was to evaluate serum prostate specific antigen (PSA) levels in women with menstrual disturbances and fibrocystic mastopathy. A total of 114 women with fibrocystic breast disease with cysts10 mm (group I), 62 with macrocysts10 mm (group II) and 46 healthy volunteers, who served as control subjects, were recruited for this prospective study. Each patient underwent complete gynecological examination and had performed sonography of the breasts. Moreover menstrual pattern, serum levels of free and total PSA, LH, FSH, SHBG, PRL, estradiol, progesterone, TSH, T4, as well as serum total testosterone, were evaluated in each subject. We compared serum free and total PSA levels between women with different menstrual pattern within groups of women with micro- and macrocysts. We also evaluated correlations between serum free and total PSA and hormonal/descriptive variables. We found that, in group II, women with regular menses and polymenorrhea revealed significantly higher serum free PSA than women with oligomenorrhea and secondary amenorrhea. Moreover, we found a positive correlation between serum total testosterone and total PSA in the control group and between progesterone and total PSA in group II. Our data show that serum free PSA is increased in women with regular menstrual cycles and polymenorrhea. This later relationship refers to women with macrocysts. Further studies are required to clarify the relationships between serum PSA and menstrual disturbances in women with mastopathy. |
| Databáze: | OpenAIRE |
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