Expression of chemokine receptor CCR7 is a negative prognostic factor for patients with gastric cancer: a meta-analysis
| Autor: | Peizhun Du, Hong Ren, Jing Zhao, Guangjian Huang, Yongchao Liu, Jun Gan, Xiaodan Zhang, Chenen Hu, Rajan Patel |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Receptors CCR7 Cancer Research medicine.medical_specialty Pathology Lymphovascular invasion C-C chemokine receptor type 7 Cochrane Library 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Internal medicine Biomarkers Tumor medicine Humans business.industry Hazard ratio Gastroenterology Cancer General Medicine Prognosis medicine.disease Confidence interval Survival Rate 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis Relative risk business |
| Zdroj: | Gastric Cancer. 20:235-245 |
| ISSN: | 1436-3305 1436-3291 |
| DOI: | 10.1007/s10120-016-0602-8 |
| Popis: | The prognostic significance of CC chemokine receptor type 7 (CCR7) for survival of patients with gastric cancer remains controversial. To investigate the impacts of CCR7 on clinicopathological findings and survival outcome in gastric cancer, we performed a meta-analysis. A comprehensive search in PubMed, Embase, the Cochrane Library, and the CNKI database (1966 to November 2015) was undertaken for relevant studies. The relative risk and hazard ratios with their 95 % confidence intervals were used as measures to investigate the correlation between CCR7 expression and clinicopathological findings and overall survival rate. Sensitivity analysis was conducted to assess the stability of outcomes. Fifteen eligible studies comprising 1697 participants were included in our analysis. The pooled relative risks indicated CCR7 expression was significantly associated with deeper tumor invasion [0.61, 95 % confidence interval (CI) 0.45–0.84, p = 0.003], advanced stage (0.47, 95 % CI 0.32–0.69, p |
| Databáze: | OpenAIRE |
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