Caphosol, a therapeutic option in case of cancer therapy-induced oral mucositis in children? Results from a prospective multicenter double blind randomized controlled trial
| Autor: | A.M. den Boer, Martine Raphael, H. Mekelenkamp, Wim J. E. Tissing, Gertjan J.L. Kaspers, Floor Abbink, W. J. W. Kollen, K. Zomer-Kooijker, B. H. W. Molmans |
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| Přispěvatelé: | Pediatric surgery, CCA - Innovative therapy, Faculteit Medische Wetenschappen/UMCG, Guided Treatment in Optimal Selected Cancer Patients (GUTS) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Calcium Phosphates
Male medicine.medical_specialty Adolescent medicine.medical_treatment Cancer therapy Mouthwashes Antineoplastic Agents Hematopoietic stem cell transplantation Caphosol law.invention Double blind Sepsis Randomized controlled trial Double-Blind Method law Internal medicine Neoplasms medicine Mucositis Humans Prospective Studies Prospective cohort study Child Stomatitis business.industry SUPERSATURATED CALCIUM Hematopoietic Stem Cell Transplantation STEM-CELL TRANSPLANTATION medicine.disease Surgery Oncology Child Preschool EXPERIENCE Female business |
| Zdroj: | Supportive Care in Cancer, 22(1), 3-6. Springer Verlag Supportive Care in Cancer, 22(1), 3-6 Supportive Care in Cancer, 22(1), 3-6. SPRINGER Raphael, M F, Laheij-de Boer, A M, Kollen, W J W, Mekelenkamp, H, Abbink, F C H, Kaspers, G J L, Zomer-Kooijker, K, Molmans, B H W & Tissing, W J E 2014, ' Caphosol, a therapeutic option in case of cancer therapy-induced oral mucositis in children? Results from a prospective multicenter double blind randomized controlled trial ', Supportive Care in Cancer, vol. 22, no. 1, pp. 3-6 . https://doi.org/10.1007/s00520-013-2015-0 |
| ISSN: | 0941-4355 |
| DOI: | 10.1007/s00520-013-2015-0 |
| Popis: | In pediatric oncology, chemotherapyor radiotherapy-induced oral mucositis (OM) is accompanied by decreased oral intake, pain, analgesics use, and hospital admission [1, 2]. Moreover, OM is correlated with an increased risk of sepsis [3, 4]. Recently, Caphosol, a supersaturated CaPO4 mouth rinse, became available to prevent or treat mucositis [5]. Papas et al. demonstrated Caphosol to have a beneficial prophylactic effect in adult hematopoietic stem cell transplantation (HSCT) patients, but evidence in pediatric patients is lacking [6]. We studied whether Caphosol can be used to treat OM in a prospective randomized study. |
| Databáze: | OpenAIRE |
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