Pseudoguanolide sesquiterpene lactones from Veroniopsis caudata and their in vitro antiplasmodial activities
| Autor: | David Ramanitrahasimbola, Medhi Labaïed, Philippe Rasoanaivo, Voahangy Ramanandraibe, Lengo Mambu, Francois Frappier, Marie-Thérèse Martin, Philippe Grellier, Dina L Rakotondramanana |
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| Přispěvatelé: | Laboratoire de chimie et biochimie des substances naturelles, Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN), Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC) |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
0106 biological sciences
Ethyl acetate Pharmaceutical Science Pharmacognosy Asteraceae MESH: Plants Medicinal 01 natural sciences KB Cells Analytical Chemistry MESH: Madagascar chemistry.chemical_compound Lactones Sesquiterpenes Guaiane MESH: Asteraceae Drug Discovery Tumor Cells Cultured MESH: Inhibitory Concentration 50 chemistry.chemical_classification biology [CHIM.ORGA]Chemical Sciences/Organic chemistry MESH: Drug Screening Assays Antitumor Biological activity 3. Good health [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biomolecules [q-bio.BM] MESH: Plant Leaves Molecular Medicine MESH: Sesquiterpenes Sesquiterpenes Lactone MESH: Lactones Stereochemistry MESH: Antineoplastic Agents Phytogenic MESH: KB Cells [SDV.BC]Life Sciences [q-bio]/Cellular Biology Sesquiterpene Antimalarials Inhibitory Concentration 50 Madagascar Humans MESH: Tumor Cells Cultured Pharmacology MESH: Humans Plants Medicinal Organic Chemistry biology.organism_classification MESH: Antimalarials Antineoplastic Agents Phytogenic Terpenoid In vitro 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry Drug Screening Assays Antitumor 010606 plant biology & botany |
| Zdroj: | Journal of Natural Products Journal of Natural Products, American Chemical Society, 2005, 68, pp.800-803. ⟨10.1021/np0401866⟩ Journal of Natural Products, American Chemical Society, 2005, 68 (5), pp.800-3. ⟨10.1021/np0401866⟩ |
| ISSN: | 0163-3864 1520-6025 |
| DOI: | 10.1021/np0401866⟩ |
| Popis: | Two new helenanolide sesquiterpene lactones, 1 and 2, as well as one known related structure, 11α,13-dihydrohelenalin-[2-(1-hydroxyethyl)acrylate] (3), together with 4′-β-D-O-glucopyranosyl-luteolin and ethyl 2,5-dihydroxycinnamate were isolated from an ethyl acetate extract of leaves of Vernoniopsis caudata with potent antiplasmodial activity (IC50 1.6 μg/mL) in a preliminary biological screen. The structures of the new compounds were determined by spectroscopic techniques. The three sesquiterpene lactones 1-3 displayed strong in vitro antiplasmodial activity, with IC 50 values of 1, 0.19, and 0.41 μM, respectively. However, these compounds also exhibited considerable cytotoxicity on KB cells (IC50 < 1 μM in each case). © 2005 American Chemical Society and American Society of Pharmacognosy. |
| Databáze: | OpenAIRE |
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