Central nicotinic receptors: Vomiting, ear twitching and panting
| Autor: | S. Doěić, S.K. Krstić, D.B. Beleslin |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Nicotine medicine.medical_specialty Vomiting Dimethylphenylpiperazinium Hexamethonium Compounds Receptors Nicotinic Hexamethonium Piperazines chemistry.chemical_compound Internal medicine Muscarinic acetylcholine receptor medicine Animals Injections Intraventricular business.industry Respiration General Neuroscience digestive oral and skin physiology Area postrema Brain Atropine Nicotinic agonist Endocrinology nervous system chemistry Cats Female Dimethylphenylpiperazinium Iodide business hormones hormone substitutes and hormone antagonists Acetylcholine Body Temperature Regulation Muscle Contraction medicine.drug |
| Zdroj: | Brain Research Bulletin. 11:299-302 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/0361-9230(83)90164-8 |
| Popis: | Vomiting, ear twitching and panting produced by either nicotine or dimethylphenylpiperazinium (DMPP) administered intracerebroventricularly (ICV) to the unanesthetized cat were studied and compared. On a molar basis, nicotine evoked stronger effects overall in terms of the three responses studied, but the DMPP-induced vomiting and ear twitching responses, while weaker, were of longer duration. No significant differences were found in the duration of panting evoked by these nicotinic agonists. The nicotinic blocker hexamethonium injected ICV abolished the vomiting and ear twitching caused by either ICV nicotine or ICV DMPP, but vomiting and ear twitching persisted following the ICV administration of the muscarinic blocker, atropine. Both hexamethonium and atropine depressed or abolished the panting response evoked by either ICV nicotine or ICV DMPP. In cats with ablations of the area postrema, nicotine and DMPP injected ICV did not produce the vomiting response, but ear twitching and panting still occurred. It is concluded that the ICV injection of nicotine or DMPP evoked vomiting and ear twitching in the cat by way of an action on the central nicotinic receptors. However, panting produced by these nicotinic agonists is mediated by the mimicking action of acetylcholine on central receptors having mixed nicotinic and muscarinic properties. |
| Databáze: | OpenAIRE |
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