Metabonomic Study of the Effects of Acanthopanax senticosus on Peripheral System of Rats
| Autor: | Shu-min Liu, Fang Lu, Xu-zhao Li, Shuai-nan Zhang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Pharmaceutical Science Endogeny Eleutherococcus Biology Pharmacology medicine.disease_cause Kidney Mass Spectrometry Analytical Chemistry Rats Sprague-Dawley Metabolomics Downregulation and upregulation Drug Discovery medicine Animals Lung Chromatography High Pressure Liquid Plant Extracts Myocardium Organic Chemistry Kidney metabolism Cancer Heart medicine.disease Rats Oxidative Stress medicine.anatomical_structure Complementary and alternative medicine Liver Toxicity Molecular Medicine Oxidative stress Biomarkers Spleen |
| Zdroj: | Planta medica. 81(9) |
| ISSN: | 1439-0221 |
| Popis: | Acanthopanax senticosus is extensively used to treat various nervous and cerebrovascular diseases in traditional medicinal systems in China and Russia. Ultrahigh-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry coupled with pattern recognition methods was used to investigate the effects of A. senticosus on the peripheral system in rats. The analysis of possible pathways influenced by A. senticosus was performed with MetaboAnalyst and Cytoscape software. After treatment with A. senticosus, 21 modulated metabolites in heart tissue, 20 in liver tissue, 14 in spleen tissue, 17 in lung tissue, 16 in kidney tissue, and 12 in a serum sample were identified and considered potential biomarkers of A. senticosus treatments. The regulation of some endogenous metabolites by A. senticosus could be beneficial for the treatment of several peripheral system diseases, such as hypertension, cancer, and oxidative stress, etc. However, there were also some upregulated endogenous metabolites producing potential toxicity to the peripheral system. A metabonomic analysis revealed that protection and toxicity coexisted in the effects of A. senticosus on the peripheral system, which may be a practical guide for its safe use and beneficial to the expansion of its application. |
| Databáze: | OpenAIRE |
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