Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases
| Autor: | Yunyun Yuan, Shuang Ling, Yi-Ting Zhou, Lin Zhu, Jin-Wen Xu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Aging
Anti-Inflammatory Agents Traditional Chinese medicine Review Article Biochemistry Neuroprotection Proinflammatory cytokine Psoralea Cardiovascular Physiological Phenomena Bavachalcone Diabetes Mellitus Medicine Animals Humans Obesity Bavachinin Cellular Senescence Flavonoids biology Traditional medicine QH573-671 Mechanism (biology) business.industry Cell Biology General Medicine biology.organism_classification Neobavaisoflavone Osteoporosis business Cytology Signal Transduction |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2020 (2020) |
| ISSN: | 1942-0994 |
| Popis: | During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to “inflammaging,” which is a state of chronic, systemic, sterility, low-grade inflammatory microenvironment and a key risk factor in the development of aging-related diseases. Fructus psoraleae is a traditional Chinese medical herb best known for delaying aging and treating osteoporosis. Prenylflavonoids from fructus psoraleae are the main bioactive compounds responsible for its pharmacological applications, such as beaching, bavachinin, bavachalcone, isobavachalcone, and neobavaisoflavone. In previous decades, there have been some promising studies on the pharmacology of fructus psoraleae. Here, we focus on the anti-inflammatory and antiaging diseases of five psoralea prenylflavonoids, such as cardiovascular protection, diabetes and obesity intervention, neuroprotection, and osteoporosis, and discuss the mechanism of these active ingredients for better understanding the material basis and drug application of fructus psoraleae in Chinese medicine. |
| Databáze: | OpenAIRE |
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