Epidermal growth factor as a new regulator of induction of tyrosine aminotransferase and tryptophan oxygenase by glucocorticoids
| Autor: | Naomi Fukusen, Hiroshi Kido, Nobuhiko Katunuma |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Male
medicine.medical_specialty Submandibular Gland Biophysics Endogeny Biochemistry Glucagon Tyrosine aminotransferase Glucocorticoid Structural Biology Epidermal growth factor Internal medicine Genetics medicine Animals Hepatocyte Enzyme inducer Growth Substances Glucocorticoids Molecular Biology Tyrosine Transaminase chemistry.chemical_classification biology Enzyme induction Adrenalectomy Cell Biology Tryptophan Oxygenase Rats Enzyme Endocrinology medicine.anatomical_structure Liver chemistry biology.protein hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | FEBS Letters. (2):223-226 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(87)80293-4 |
| Popis: | Epidermal growth factor (EGF) dose-dependently enhanced the induction of tyrosine aminotransferase and tryptophan oxygenase by glucocorticoids in primary cultures of adult rat hepatocytes without itself having any effect on these enzymes in the absence of glucocorticoids. The amplifications were observed even with dexamethasone at high concentrations (10 −6 M−10 −5 M) that had a maximal effect. EGF had no effect on induction of tyrosine aminotransferase by glucagon or Bt 2 cAMP. The effect of EGF was also observed in adrenal-ectomized and submaxillar gland-ectomized rats. These results suggest that EGF is an endogenous amplifier of the action of glucocorticoids. |
| Databáze: | OpenAIRE |
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