The Association Between Genetic Risk Factors and the Size of Intracranial Aneurysms at Time of Rupture
| Autor: | Irene C. van der Schaaf, Franciscus J. Wolters, Ynte M. Ruigrok, Femke N G van 't Hof, Ingeborg Rasing, Gabriel J.E. Rinkel, Rachel Kleinloog |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Subarachnoid hemorrhage Adolescent Genotype Genome-wide association study Single-nucleotide polymorphism Aneurysm Ruptured Polymorphism Single Nucleotide Young Adult Aneurysm Risk Factors Humans Medicine Genetic Predisposition to Disease cardiovascular diseases Aged Genetic association Aged 80 and over Rupture Spontaneous medicine.diagnostic_test business.industry Angiography Digital Subtraction Intracranial Aneurysm Digital subtraction angiography Middle Aged medicine.disease Angiography Female Surgery Neurology (clinical) Radiology Tomography X-Ray Computed business |
| Zdroj: | Neurosurgery. 73:705-708 |
| ISSN: | 0148-396X |
| Popis: | BACKGROUND Genetic risk factors for intracranial aneurysms may influence the size of aneurysms. OBJECTIVE To assess the association between genetic risk factors and the size of aneurysms at the time of rupture. METHODS Genotypes of 7 independent single-nucleotide polymorphisms (SNPs) of the 6 genetic risk loci identified in genome-wide association studies of patients with intracranial aneurysms were obtained from 700 Dutch patients with an aneurysmal subarachnoid hemorrhage (1997-2007) previously genotyped in the genome-wide association studies; 255 additional Dutch patients with an aneurysmal subarachnoid hemorrhage (2007-2011) were genotyped for these SNPs. Aneurysms were measured on computerized tomography angiography or digital subtraction angiography. The mean aneurysm size (with standard error) was compared between patients with and without a genetic risk factor by the use of linear regression. The association between SNPs and size was assessed for single SNPs and for the combined effect of SNPs by using a weighted genetic risk score. RESULTS Single SNPs showed no association with aneurysm size, nor did the genetic risk score. CONCLUSION The 6 genetic risk loci have no major influence on the size of aneurysms at the time of rupture. Because these risk loci explain no more than 5% of the genetic risk, other genetic factors for intracranial aneurysms may influence aneurysm size and thereby proneness to rupture. |
| Databáze: | OpenAIRE |
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