Maturation of the infant rhesus macaque gut microbiome and its role in the development of diarrheal disease
| Autor: | Sara M. Hendrickson, Katrine Whiteson, Ilhem Messaoudi, Tasha Barr, Mark K. Slifka, Nicholas S. Rhoades, Kamm Prongay, Leanne Gill, Andrew J. Haertel, Laura Garzel |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Diarrhea
Male Aging lcsh:QH426-470 Gut flora medicine.disease_cause Pathogenesis 03 medical and health sciences 0302 clinical medicine Prevotella medicine Animals Humans Microbiome Child Developing Countries lcsh:QH301-705.5 Phylogeny 030304 developmental biology 2. Zero hunger 0303 health sciences biology Bacteria Campylobacter Research Developed Countries Gastrointestinal Microbiome Infant biology.organism_classification Macaca mulatta 3. Good health Anti-Bacterial Agents Rhesus macaque lcsh:Genetics Animals Newborn lcsh:Biology (General) Child Preschool Immunology Carrier State Female Disease Susceptibility Metagenomics medicine.symptom 030217 neurology & neurosurgery Biomarkers Genome Bacterial |
| Zdroj: | Genome Biology, Vol 20, Iss 1, Pp 1-16 (2019) Genome Biology |
| Popis: | Background Diarrhea is the second leading cause of death in children under 5 years of age. Enhanced understanding of causal pathways, pathogenesis, and sequelae of diarrhea is urgently needed. Although the gut microbiota is believed to play a role in susceptibility to diarrheal diseases, our understanding of this association remains incomplete. Infant rhesus macaques (Macaca mulatta) are susceptible to diarrhea making them an ideal model to address this question. Results The maturation of the infant rhesus macaque gut microbiome throughout the first 8 months of life occurs in a similar pattern as that described for human infants. Moreover, the microbiome of the captive reared infant rhesus macaque more closely resembles that of human infants in the developing world than in the western world. Importantly, prior to disease onset, the gut microbiome of infants that later develop diarrhea is enriched in pathways of immunomodulatory metabolite synthesis, while those of infants that remain asymptomatic are enriched in pathways for short-chain fatty acid production. We identify Prevotella strains that are more abundant at 1 month in infants that later develop diarrhea. At 8 months, the microbiomes of animals that experience diarrhea show increased abundance of Campylobacter and a reduction in Helicobacter macacae. Conclusion The composition of the microbial community could provide a phenotypic marker of an infant’s susceptibility to diarrheal disease. Given the significant physiological and immunological similarities between human and nonhuman primates, these findings provide potential markers of susceptibility to diarrhea that could be modulated to improve infant health, especially in the developing world. Electronic supplementary material The online version of this article (10.1186/s13059-019-1789-x) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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