Lower Urinary Tract Symptoms in Subjects with Subclinical Cerebral White Matter Lesions

Autor: Sylvia W.S. Lee, Yuki Yu-Ting Wong, Pauline Kwan, Vincent Mok, Chi-Hang Yee, Winnie C.W. Chu, Ching Leung, Jenny Xin Li, Chi-Fai Ng
Rok vydání: 2018
Předmět:
Zdroj: Journal of Aging Research
Journal of Aging Research, Vol 2018 (2018)
ISSN: 2090-2204
Popis: Aim. We assessed the impact of cerebral white matter lesions (WMLs) on lower urinary tract symptoms in subjects with normal neurological and cognitive function.Methods. A cohort of community-dwelling subjects aged ≥65 years were recruited to undergo MRI brain assessment. WMLs were graded using the Fazekas scale from 0 to 3. A separate telephone interview was carried out to assess the urinary symptoms in these subjects using the questionnaire Overactive Bladder-Validated 8-Question Awareness Tool (OAB-V8).Results. 800 community-dwelling elderly subjects were recruited to undergo MRI brain. In this cohort, 431 subjects responded to the telephone interview concerning their urinary symptoms. Among the respondents, 21.1% did not exhibit any WML on their MRI brain. Most of the subjects (52.6%) exhibited grade 1 WML. On logistic regression, age was found to be positively correlated with the Fazekas score (correlation coefficient 0.203,p≤0.01). Using a cutoff of 8 on OAB-V8, 22% of the respondents experienced OAB. Presence of WML, hypertension, or diabetes mellitus was not found to be correlated with storage urinary symptoms or OAB-V8 total score. Multiple logistic regression analysis did not show the presence of WML to be associated with the diagnosis of OAB (adjusted OR 1.13, 95% CI 0.65–1.96,p=0.659).Conclusions. WML is associated with age and is common in the elderly population. Mild WML is subclinical, with no obvious neurological and urinary symptoms. Our cohort did not demonstrate a relationship between WML and lower urinary tract symptoms.
Databáze: OpenAIRE
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