Body mass index and the visceral adipose tissue expression of IL-6 and TNF-alpha are associated with the morphological severity of non-alcoholic fatty liver disease in individuals with class III obesity
| Autor: | Gislaine Candida Batista Jorge, Sérgio Henrique Sousa Santos, Erivelton Pereira dos Santos, Alfredo Maurício Batista De-Paula, André Luiz Sena Guimarães, Antonio Sergio Barcala Jorge, Ludmilla Regina de Souza, João Marcus Oliveira Andrade, Alanna Fernandes Paraíso, Christine Mendes Silveira |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Tecido adiposo Adipose tissue Bariatric Surgery White adipose tissue Intra-Abdominal Fat Severity of Illness Index Body Mass Index 03 medical and health sciences Young Adult 0302 clinical medicine Non-alcoholic Fatty Liver Disease Internal medicine medicine Humans Prospective cohort study Índice de massa corporal Nutrition and Dietetics business.industry Class III obesity Interleukin-6 Tumor Necrosis Factor-alpha Gene Expression Profiling Fatty liver nutritional and metabolic diseases Citocinas Middle Aged medicine.disease Obesity Morbid 030104 developmental biology Endocrinology Cross-Sectional Studies Obesidade 030211 gastroenterology & hepatology Female Steatosis Steatohepatitis Inflammation Mediators business Fígado - Doenças Body mass index Biomarkers |
| Zdroj: | Repositório Institucional da UFMG Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
| Popis: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Objectives: to analyze the mRNA expression of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) in the liver and white adipose tissue samples of individuals with class III obesity (body mass index ≥40.0 kg/m2) with non-alcoholic fatty liver disease (NAFLD). Methods: this cross-sectional study included patients with class III obesity exhibiting early or late morphological presentation of NAFLD (non-alcoholic hepatic steatosis [NAFL], n = 8 and non-alcoholic steatohepatitis [NASH], n = 13, respectively). All patients underwent bariatric surgery and peripheral blood, liver, and visceral white adipose tissue (WAT) samples were collected. Socio-demographic, anthropometric, clinical, plasma biochemical, and nutritional characteristics of each study subject were assessed and compared between patients presenting with NAFL and NASH. IL-6 and TNF-α mRNA expression in the liver and WAT samples were measured by using quantitative real time-polymerase chain reaction (qRT-PCR). Results: individuals with class III obesity and NASH showed higher body mass index (BMI) and higher IL-6 and TNF-α mRNA expression in the WAT compared to that of patients with NAFL (p = 0.01, for all associations). Conclusions: individuals with class III obesity with higher morphological severity of NAFLD exhibited higher BMI and higher IL-6 and TNF-α expression in the WAT. Future prospective studies are warranted to determine how BMI, IL-6, and TNF-α affect the progression of NAFLD in individuals with class III obesity. |
| Databáze: | OpenAIRE |
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