The Bal I and Msp I Polymorphisms in the dopamine D3 receptor gene display, linkage disequilibrium with each other but no association with Tourette syndrome
| Autor: | Eric J. Devor, Rebecca M. Dill-Devor, Harry J. Magee |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Linkage disequilibrium Candidate gene Biology Tourette syndrome Deoxyribonuclease HpaII Linkage Disequilibrium law.invention law Dopamine receptor D3 Polymorphism (computer science) Genetics medicine Humans Deoxyribonucleases Type II Site-Specific Gene Biological Psychiatry Genetics (clinical) Polymerase chain reaction Receptors Dopamine D2 Receptors Dopamine D3 medicine.disease Psychiatry and Mental health Female Restriction fragment length polymorphism Polymorphism Restriction Fragment Length Tourette Syndrome |
| Zdroj: | Psychiatric Genetics. 8:49-52 |
| ISSN: | 0955-8829 |
| DOI: | 10.1097/00041444-199800820-00003 |
| Popis: | The D3-dopamine receptor gene, DRD3, has been considered as a candidate gene in several disorders in which the dopaminergic system has been implicated including Tourette syndrome and schizophrenia. The DRD3 studies to date have all used as the gene marker a Bal I polymerase chain reaction restriction fragment length polymorphism (PCR RFLP). There have been recent reports on a second marker, an Msp I PCR RFLP, that lies 40 kb downstream. We have typed a sample of 16 Tourette syndrome families with both markers and observed significant linkage disequilibrium between the two markers but no apparent association of either marker with Tourette syndrome. |
| Databáze: | OpenAIRE |
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