Incidence of jaw lesions and activity and gene expression of hepatic P4501A enzymes in mink (Mustela vison) exposed to dietary 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran
| Autor: | John L. Newsted, Matthew J. Zwiernik, Robert A. Budinsky, John P. Giesy, Jeremy N. Moore, Steve Wiseman, Xiaowei Zhang, Denise P. Kay, Scott D. Fitzgerald, Jane E. Link, Steven J. Bursian, Virunya S. Bhat, Nora M. Bello |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Polychlorinated Dibenzodioxins Endpoint Determination Offspring Health Toxicology and Mutagenesis Population Gene Expression Biology Internal medicine biology.animal Cytochrome P-450 CYP1A1 medicine Animals Environmental Chemistry Weaning Juvenile Mink Toxicity Tests Chronic education Toxic equivalency factor Benzofurans education.field_of_study Incidence Diet stomatognathic diseases Endocrinology Jaw Liver Toxicity Female Histopathology |
| Zdroj: | Environmental Toxicology and Chemistry. 31:2545-2556 |
| ISSN: | 0730-7268 |
| Popis: | This study assessed the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and 2,3,7,8 tetrachlorodibenzofuran (TCDF) on the incidence of jaw lesions and on hepatic cytochrome P4501A (CYP1A) endpoints in mink (Mustela vison). Adult female mink were assigned randomly to one of 13 dietary treatments (control and four increasing doses of TCDD, PeCDF, or TCDF) and provided spiked feed for approximately 150 d (60 d prior to breeding through weaning of offspring at 42 d post-parturition). Offspring were maintained on their respective diets for an additional 150 d. Activity of hepatic CYP1A enzymes in adult and juvenile mink exposed to TCDD, PeCDF, or TCDD was generally greater compared with controls, but changes in other CYP1A endpoints were less consistent. Histopathology of the mandible and maxilla of juvenile mink suggested a dose-related increase in the incidence of jaw lesions. The dietary effective doses (ED) for jaw lesions in 50% of the population (ED50) were estimated to be 6.6, 14, and 149 ng/kg body weight (bw)/d for TCDD, PeCDF, and TCDF, respectively. The relative potencies of PeCDF and TCDF compared with TCDD based on ED10, ED20, and ED50 values ranged from 0.5 to 1.9 and 0.04 to 0.09, respectively. These values are within an order of magnitude of the World Health Organization toxic equivalency factor (TEFWHO) values of 0.3 and 0.1 for PeCDF and TCDF, respectively. Environ. Toxicol. Chem. 2012; 31: 2545–2556. © 2012 SETAC |
| Databáze: | OpenAIRE |
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