Mechanical stimulation of the plantar foot surface attenuates soleus muscle atrophy induced by hindlimb unloading in rats
| Autor: | Charles S. Layne, Mark S. F. Clarke, Daniel A. Martinez, Antonios Kyparos, Daniel L. Feeback |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Physiology Muscle Fibers Skeletal Stimulation Hindlimb Atrophy Physical Stimulation Physiology (medical) Internal medicine medicine Animals Myocyte Rats Wistar Muscle Skeletal Soleus muscle Proprioception Weightlessness business.industry Anatomy medicine.disease Musculoskeletal Manipulations Muscle atrophy Rats Muscular Atrophy Treatment Outcome Endocrinology Hindlimb Suspension medicine.symptom business |
| Zdroj: | Journal of Applied Physiology. 99:739-746 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00771.2004 |
| Popis: | Unloading-induced muscle atrophy occurs in the aging population, bed-ridden patients, and astronauts. This study was designed to determine whether dynamic foot stimulation (DFS) applied to the plantar surface of the rat foot can serve as a countermeasure to soleus muscle atrophy normally observed in hindlimb unloaded (HU) rats. Forty-four mature (6 mo old), male Wistar rats were randomly assigned to ambulatory control, HU alone, HU with active DFS (i.e., plantar contact with active inflation), HU with passive DFS (i.e., plantar contact without active inflation), and HU while wearing a DFS boot with no plantar contact groups. Application of active DFS during HU significantly counteracted the atrophic response by preventing approximately 85% of the reduction in type I myofiber cross-sectional area (CSA) in the soleus while preventing approximately 57% of the reduction in type I myofiber CSA and 43% of the reduction in type IIA myofiber CSA of the medial gastrocnemius muscle. Wearing of a DFS boot without active inflation prevented myofiber atrophy in the soleus of HU animals in a fashion similar to that observed in HU animals that wore an actively inflated DFS boot. However, when a DFS boot without plantar surface contact was worn during HU, no significant protection from HU-induced myofiber atrophy was observed. These results illustrate that the application of mechanical foot stimulation to the plantar surface of the rat foot is an effective countermeasure to muscle atrophy induced by HU. |
| Databáze: | OpenAIRE |
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