Prediction of Long-Term Mortality Based on Neutrophil-Lymphocyte Ratio After Percutaneous Coronary Intervention
| Autor: | Heesang Song, Kyung-Hoon Sun, Sam Cheol Kim, Young-Min Lee, Dong-Hyun Choi, Seo-Won Choi, Keun Ho Park, Seong-Ho Kang |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Neutrophils medicine.drug_class medicine.medical_treatment 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Troponin T Interquartile range Internal medicine Natriuretic Peptide Brain Republic of Korea medicine Natriuretic peptide Humans Lymphocytes 030212 general & internal medicine Aged Aged 80 and over business.industry Mortality rate fungi Percutaneous coronary intervention General Medicine Middle Aged medicine.disease Peptide Fragments Death Heart failure Conventional PCI Cardiology Female business |
| Zdroj: | The American Journal of the Medical Sciences. 351:467-472 |
| ISSN: | 0002-9629 |
| DOI: | 10.1016/j.amjms.2015.12.022 |
| Popis: | The preprocedural neutrophil-lymphocyte ratio (NLR) is related to adverse outcomes in patients with coronary artery disease. We hypothesized that high NLR is a predictor of cardiac death after percutaneous coronary intervention (PCI). The objective of this investigation was to assess the associations of NLR, high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B type natriuretic peptide (NT-proBNP) with the occurrence of cardiac death after PCI.The NLR, hs-cTnT and NT-proBNP were analyzed in 372 patients who underwent PCI. The primary end point was cardiac death.The median NLR was 2.3 (interquartile range: 1.5-4.1). There were 21 cardiac death events during a mean follow-up duration of 25.8 months. With the NLR cutoff level set to 3.3 using the receiver-operating characteristic curve, the sensitivity and specificity for differentiating between the group with cardiac death and the group without cardiac death were 85.7% and 59.3%, respectively. Kaplan-Meier analysis revealed that the higher NLR group (≥3.3) had a significantly higher cardiac death rate than the lower NLR group (3.3) (11.1% versus 1.4%, log-rank: P0.0001). This value was more useful in patients with heart failure (NT-proBNP ≥ 300ng/L) or myocardial injury (hs-cTnT ≥ 100ng/L).The outcomes of the current study demonstrate that high NLR is a predictor of cardiac death after PCI, especially in patients with heart failure or myocardial injury. |
| Databáze: | OpenAIRE |
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