A 6-week double-blind comparison of amlodipine and placebo in patients with stable exertional angina pectoris receiving concomitant beta-blocker therapy
| Autor: | W Klein, Veselin Mitrovic, Helmut Neuss, Martin Schlepper, P Fitscha, W Meisner, G Cocco, G Prager |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Vasodilator Agents Adrenergic beta-Antagonists Physical Exertion Placebo Severity of Illness Index law.invention Angina Pectoris Angina Nitroglycerin Pharmacotherapy Randomized controlled trial Double-Blind Method law Internal medicine Statistical significance Severity of illness medicine Humans Amlodipine Aged Pharmacology business.industry Middle Aged medicine.disease Calcium Channel Blockers Treatment Outcome Concomitant Cardiology Exercise Test Drug Therapy Combination Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 17 |
| ISSN: | 0160-2446 |
| Popis: | This study was a multicenter, double-blind comparison of the antianginal efficacy and safety of amlodipine and placebo as adjunctive therapy with constant recommended maintenance doses of beta-blockers. Patients with stable exertional angina pectoris were randomized to placebo or amlodipine at a starting dose of 5 mg once daily. The amlodipine dose was adjusted to 10 mg daily after 2 weeks if angina attacks were not abolished. Antianginal efficacy was assessed throughout the study with angina diaries, investigators' and patients' global evaluations, and with bicycle exercise tests during a placebo run-in period (baseline) and after 2 and 6 weeks of double-blind treatment. On baseline-final analysis, the exercise time to angina onset increased by 13% with amlodipine compared to 6% with placebo (p < 0.05). The total exercise time increased by 11% on amlodipine compared with 2% on placebo, though this difference did not reach statistical significance. Angina attack frequency and nitroglycerin consumption were both reduced by adding amlodipine to beta-blocker treatment. Amlodipine in combination with beta-blocker therapy was well tolerated, with a low incidence of side effects and laboratory test abnormalities. The study showed clearly that addition of amlodipine to beta-blocker therapy in patients with stable angina pectoris was well tolerated and gave improved antianginal efficacy. |
| Databáze: | OpenAIRE |
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