Ischemic Damage and Subsequent Proliferation of Oligodendrocytes in Hippocampal CA1 Region following Repeated Brief Cerebral Ischemia
| Autor: | Mohammad Ghazizadeh, Akiko Adachi, Hiro Eda, Shigeru Sato, Yoshihiro Sasaki |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty Time Factors Ischemia Hippocampal formation Hippocampus Brief periods Pathology and Forensic Medicine Necrosis Microscopy Electron Transmission Phagocytosis Proliferating Cell Nuclear Antigen Glial Fibrillary Acidic Protein parasitic diseases Occlusion Animals Medicine cardiovascular diseases skin and connective tissue diseases Molecular Biology Cell Proliferation Glial fibrillary acidic protein biology business.industry Pyramidal Cells Cell Biology General Medicine medicine.disease Immunohistochemistry Oligodendrocyte Proliferating cell nuclear antigen Disease Models Animal Oligodendroglia medicine.anatomical_structure Ischemic Attack Transient Astrocytes Anesthesia biology.protein sense organs Gerbillinae business Neuroglia Astrocyte |
| Zdroj: | Pathobiology. 76:204-211 |
| ISSN: | 1423-0291 1015-2008 |
| Popis: | Changes in oligodendrocytes and astrocytes following repeated brief periods of ischemia were studied in gerbils. The repeated brief periods of cerebral ischemia were produced by occlusion of bilateral common arteries for 3 × 3 min at 1-hour intervals. Oligodendrocytes and astrocytes in hippocampal CA1 regions were examined on 1, 3, 7 and 14 days after ischemia. Seven days after ischemia reperfusion, astrocytes, large pale and small dark oligodendrocytes entered the necrotic pyramidal neuron layer and coexisted with microglia. The necrotic matter of neurons and phagolysosome was observed in cytoplasm of some large pale and small dark oligodendrocytes. Most oligodendrocytes also intermingled with reactive astrocytes. These reactive astrocytes showed glial fibrillary acidic protein-positive reaction. Furthermore, proliferating cell nuclear antigen-positive cells increased markedly 7 days after reperfusion. We conclude that the repeated brief cerebral ischemia caused proliferation of oligodendrocytes and astrocytes, and oligodendrocytes may play a phagocytic role for clearance of necrotic matter of neurons. |
| Databáze: | OpenAIRE |
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