Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19
Autor: | Abakar Magomedov, Daniel Zickler, Stoyan Karaivanov, Annika Kurreck, Frédéric H. Münch, Julian Kamhieh-Milz, Caroline Ferse, Andreas Kahl, Sophie K. Piper, Kai-Uwe Eckardt, Thomas Dörner, Jan Matthias Kruse |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Science Severity of Illness Index Article Cohort Studies Thromboembolism Humans coagulation profile Blood Coagulation Aged Viscoelastic testing Venous Thrombosis Respiratory tract diseases Anticoagulants COVID-19 Blood Coagulation Disorders Middle Aged Thrombelastography COVID-19 Drug Treatment Medicine Infectious diseases Female 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit |
Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
Popis: | COVID 19 is associated with a hypercoagulable state and frequent thromboembolic complications. For how long this acquired abnormality lasts potentially requiring preventive measures, such as anticoagulation remains to be delineated. We used viscoelastic rotational thrombelastometry (ROTEM) in a single center cohort of 13 critical ill patients and performed follow up examinations three months after discharge from ICU. We found clear signs of a hypercoagulable state due to severe hypofibrinolysis and a high rate of thromboembolic complications during the phase of acute illness. Three month follow up revealed normalization of the initial coagulation abnormality and no evidence of venous thrombosis in all thirteen patients. In our cohort the coagulation profile was completely normalized three months after COVID-19. Based on these findings, discontinuation of anticoagulation can be discussed in patients with complete venous reperfusion. |
Databáze: | OpenAIRE |
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