Association of Antipituitary Antibody and Type 2 Iodothyronine Deiodinase Antibody in Patients with Autoimmune Thyroid Disease
| Autor: | Katsuhiko Tsunekawa, Isao Kobayashi, Takayuki Kasahara, M Nara, Masami Murakami, Koji Seki, Shigeki Yabe, Michio Nishino, Takayuki Ogiwara, Rieko Nakahara |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male endocrine system Pituitary gland medicine.medical_specialty Adolescent endocrine system diseases Hashimoto's disease Endocrinology Diabetes and Metabolism Graves' disease education Thyroid Gland Enzyme-Linked Immunosorbent Assay Hashimoto Disease Iodide Peroxidase Endocrinology Antigen Internal medicine mental disorders medicine Humans Immunoprecipitation Child Aged Autoantibodies Aged 80 and over biology business.industry Thyroid Case-control study Middle Aged medicine.disease Graves Disease medicine.anatomical_structure Case-Control Studies Pituitary Gland Iodothyronine deiodinase Immunology biology.protein Female Antibody business psychological phenomena and processes |
| Zdroj: | Endocrine Journal. 52:691-699 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.52.691 |
| Popis: | Antipituitary antibody (APA) has been reported to be detected in patients with autoimmune thyroid disease. Type 2 iodothyronine deiodinase (D2) is expressed in both pituitary gland and thyroid gland. We studied the association of APA and D2 peptide antibody in patients with autoimmune thyroid disease. Rat pituitary gland homogenate and D2 peptide were used as antigens in the present study. APA and D2 peptide antibodies were measured by enzyme-linked immunosorbent assay (ELISA) in sera obtained from 42 patients with Hashimoto's disease, 26 patients with Graves' disease and 70 healthy control subjects. Moreover, D2 activity precipitation assay was performed in some patients with Hashimoto's disease. APA and D2 peptide antibody were elevated in patients with Hashimoto's disease and patients with Graves' disease, compared with control subjects. APA was positive in 32.4% (22/68), D2 peptide antibody was positive in 26.5% (18/68) of patients with autoimmune thyroid disease. APA was positive in 31.0% (13/42) of patients with Hashimoto's disease and 34.6% (9/26) of patients with Graves' disease. D2 peptide antibody was positive in 26.2% (11/42) of patients with Hashimoto's disease and 26.9% (7/26) of patients with Graves' disease. D2 peptide antibody was correlated with APA in patients with autoimmune thyroid disease. Moreover, precipitation of D2 activity was increased in some patients with Hashimoto's disease including a patient who also had idiopathic diabetes insipidus, and was correlated with D2 peptide antibody. These results suggest that D2 antibody may be associated with APA in patients with autoimmune thyroid disease. |
| Databáze: | OpenAIRE |
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