Plasma androgens during the luteal phase in a case of true hermaphroditism with bilateral ovotestis
| Autor: | K. Nahoul, Dominique Tater, Robert Scholler, J.-P. Bercovici, Thierry Maudelonde |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Adolescent medicine.drug_class media_common.quotation_subject Disorders of Sex Development Radioimmunoassay Luteal phase Genitalia Male In Vitro Techniques Luteal Phase Biochemistry Dexamethasone Endocrinology Internal medicine Testis medicine True hermaphroditism Humans Testosterone Androstenedione Menstrual cycle media_common Ovotestis Chemistry Ovary Dehydroepiandrosterone Luteinizing Hormone Androgen medicine.disease medicine.anatomical_structure Karyotyping Androgens Cosyntropin Female Follicle Stimulating Hormone Corpus luteum |
| Zdroj: | Journal of steroid biochemistry. 22(5) |
| ISSN: | 0022-4731 |
| Popis: | A true hermaphrodite with a bilateral ovotestis and a 46 XX karyotype was studied. This 14-year old subject developed ambiguous puberty with bilateral gynecomastia and stage IV pubic hair. Relatively high level of testosterone (T) (2.80 ng/ml), was found. The 5α-reductase activity for T in the pubic skin was similar to that observed in normal adult males. A hemorrhagic corpus luteum in the left ovotestis was observed at laparotomy. The luteal phase immediately after dexamethasone administration (1 mg/day for 7 days) was characterized by a significant decrease of plasma androgens, T and androstenedione (A). The constantly low level of T (0.30 ng/ml) during the luteal phase in this subject did not appear to be due to the previously administered dexamethasone. This decrease of T production in the luteal phase might be secondary either to the increase of the estradiol-17β (E2) secreted by the corpus luteum or to the decrease of LH levels. Both mechanisms might act concomitantly. |
| Databáze: | OpenAIRE |
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