Development of Ring Opening Mini-Emulsion Polymerisation of N-Carboxyanhydride Monomers for the Formation of Polypeptide Nanoparticles
| Autor: | Judge, Nicola |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| DOI: | 10.25419/rcsi.21311772.v1 |
| Popis: | The aim of this work was to increase the understanding and library of polypeptide nanoparticles synthesised by ring-opening mini-emulsion polymerisation of N-Carboxyanhydride amino acid monomers. Initially the conditions of the emulsion will be investigated in order to afford facile tuneability of the system. Taking inspiration from previous reports stereochemistry, nature of the amino acid polymerised and theoretical secondary structure was also examined with the aim to achieving statistical differences in size and morphology. Employing the techniques previously described any initial differences observed are to be thoroughly investigated in order to eliminate any bias encountered by one technique. Once the limitations and boundaries of the basis system are fully understood it should enable the application of functionalised amino acids to afford nanoparticles with defined core and shell functionality. It is thought that this alongside tuning of the core density through solid content and core to surfactant ratio by mass will afford a highly versatile delivery system of active compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|