Apolipoprotein C1 promotes prostate cancer cell proliferation in vitro
| Autor: | Shunliang Yang, Li‐na Sun, Tengyue Zeng, Hu Zhao, Weipeng Su, Dong Wang, Weizhen Wu |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell cycle checkpoint Health Toxicology and Mutagenesis Toxicology urologic and male genital diseases Biochemistry 03 medical and health sciences Prostate cancer 0302 clinical medicine RNA interference DU145 Survivin medicine Gene silencing Molecular Biology Research Articles cell apoptosis Cell growth Chemistry General Medicine apolipoprotein C1 medicine.disease prostate cancer 030104 developmental biology cell proliferation Apoptosis 030220 oncology & carcinogenesis Cancer research Molecular Medicine Research Article |
| Zdroj: | Journal of Biochemical and Molecular Toxicology |
| ISSN: | 1099-0461 1095-6670 |
| Popis: | Here, we aimed to investigate the carcinogenic effects of apolipoprotein C1 (APOC1) in prostate cancer (PCa). APOC1 expression was evaluated in PCa and normal prostate specimens, and lentivirus‐mediated RNA interference was used to knockdown APOC1 in DU145 cells. The effects of APOC1 silencing on cell proliferation, cell cycle arrest, and apoptosis were assessed. APOC1 expression was much higher in PCa tissues than in normal tissues. Moreover, APOC1 silencing inhibited cell proliferation and colony formation, arrested cell cycle progression, and enhanced apoptosis in DU145 cells. Additionally, APOC1 silencing decreased survivin, phospho‐Rb, and p21 levels and increased cleaved caspase‐3 expression. These data supported the procarcinogenic effects of APOC1 in the pathogenesis of PCa and suggested that targeting APOC1 may have applications in the treatment of PCa. |
| Databáze: | OpenAIRE |
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