The prevention of postoperative nausea and vomiting using a combination of ondansetron and droperidol
| Autor: | I. J. Wrench, J. E. H. Ward, G. J. Hobbs, A. D. Walder |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Combination therapy Vomiting medicine.drug_class Nausea medicine.medical_treatment Ondansetron Postoperative Complications medicine Humans Antiemetic Droperidol Morphine business.industry Patient-controlled analgesia Analgesia Patient-Controlled Middle Aged Surgery Anesthesiology and Pain Medicine Anesthesia Antiemetics Drug Therapy Combination Female medicine.symptom business Postoperative nausea and vomiting medicine.drug |
| Zdroj: | Anaesthesia. 51:776-778 |
| ISSN: | 0003-2409 |
| DOI: | 10.1111/j.1365-2044.1996.tb07895.x |
| Popis: | Summary We have studied the effect of combination antiemetic therapy (ondansetron and droperidol) with morphine delivered by patient-controlled analgesia following major gynaecological surgery. Sixty patients were randomly allocated to one of three treatment regimens; ondansetron alone (4 mg bolus and 0.13 mg.ml-1 in the morphine solution), droperidol alone (1.25 mg bolus and 0.05 mg.ml-1 in the morphine solution), or both drugs in combination. For the first 12 postoperative hours, patients receiving combination therapy experienced significantly less nausea than those receiving single antiemetic therapy (p < 0.001). There was no difference between the regimens from 12 to 18 h. We conclude that a combination of ondansetron and droperidol added to morphine in a patient-controlled analgesia system reduces postoperative nausea to a greater extent than treatment with either drug alone following major gynaecological surgery. |
| Databáze: | OpenAIRE |
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