Impact of time to second transurethral resection on oncological outcomes of patients with high-grade T1 bladder cancer treated with intravesical Bacillus Calmette-Guerin
| Autor: | Paulo Mota, Luigi Cormio, Francesca Sanguedolce, Estevão Lima, Emanuel Carvalho-Diaz, Alessandro Veccia, Beppe Calò, Marco Chirico, Giuseppe Carrieri, Riccardo Autorino, Ugo Falagario |
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| Rok vydání: | 2019 |
| Předmět: |
Nephrology
Male medicine.medical_specialty Time Factors Urology Population 030232 urology & nephrology Cystectomy Group B Disease-Free Survival Resection 03 medical and health sciences 0302 clinical medicine Adjuvants Immunologic Urethra Internal medicine Medicine Intravesical bacillus Calmette-Guerin Humans education Aged Neoplasm Staging Retrospective Studies education.field_of_study Bladder cancer business.industry Proportional hazards model Middle Aged medicine.disease Combined Modality Therapy Progression-Free Survival Survival Rate Administration Intravesical Treatment Outcome Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Concomitant BCG Vaccine Female Neoplasm Grading business |
| Zdroj: | World journal of urology. 38(12) |
| ISSN: | 1433-8726 |
| Popis: | To determine the impact of time to restaging transurethral resection (Re-TUR) on recurrence-free survival (RFS), progression-free survival (PFS), and cancer specific survival (CSS) of patients with high-grade T1 bladder cancer (BC) treated with intravesical Bacillus Calmette–Guerin (BCG). Our prospectively maintained NMIBC databases were queried to identify patients with high-grade T1 BC who underwent Re-TUR before receiving intravesical BCG treatment (induction + 1-year maintenance). Patients were divided into three groups based on time to Re-TUR (group A: ≤ 6 weeks; group B: > 6–12 weeks; group C: > 12–18 weeks). Kaplan–Meier plots were used to estimate differences in RFS, PFS, and CSS. Multivariate Cox regression analysis was used to assess the impact of time to Re-TUR on oncological outcomes. Overall, 269 high-grade T1 BC patients were eligible for the analysis. Nineteen (7.1%) had concomitant CIS. Median follow-up was 49.3 (IQR 25–65) months. Kaplan–Meier plots showed no differences in RFS, PFS, and CSS between the three groups. Multivariate Cox regression analysis showed that Group B had a slightly better RFS, while the other outcomes were not affected by time to Re-TUR. This is the first study testing the role of time to Re-TUR in a homogeneous population of patients with high-grade T1 BC who received complete BCG treatment. The study challenged the concept the sooner the Re-TUR the better, since time to Re-TUR did not significantly affect oncological outcomes. |
| Databáze: | OpenAIRE |
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