Kruppel, a Drosophila segmentation gene, participates in the specification of neurons and glial cells
| Autor: | Nipam H. Patel, Fernando Jiménez, Susana Romani, Herbert Jäckle, Heike Taubert, Michael Hoch |
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| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Central Nervous System
Nervous system Embryology Time Factors animal structures Mutant Kruppel-Like Transcription Factors Genes Insect Biology Krüppel Precursor cell Peripheral Nervous System medicine Animals Drosophila Proteins Tissue Distribution Fluorescent Antibody Technique Indirect Transcription factor Neurons Microscopy Confocal Neurogenesis Anatomy Immunohistochemistry Cell biology DNA-Binding Proteins Repressor Proteins Segmentation gene medicine.anatomical_structure nervous system Mutation Drosophila Nervous System Diseases Neuroglia Transcription Factors Developmental Biology Minigene |
| Zdroj: | Mechanisms of Development |
| Popis: | We report that the Drosophila segmentation gene Kruppel ( Kr ) is expressed in neural precursor cells, neurons and glia cells at different stages of neurogenesis and that Kr mutants develop aberrant peripheral (PNS) and central (CNS) nervous systems. Expression derived from a Kr minigene rescues the segmentation defects but these embryos continue to lack most of the neural Kr activity. Phenotypic analysis of the rescued embryos indicates that, in addition to overall effects on the PNS and CNS structure via its segmentation role, Kr expression in the nervous system is functionally required for establishing particular neural and glial fates. |
| Databáze: | OpenAIRE |
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