Age-associated proinflammatory elastic fiber remodeling in large arteries
| Autor: | Kimberly R. McGraw, Robert E. Monticone, Soo Hyuk Kim, Mingyi Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Aging Vascular Remodeling Article Proinflammatory cytokine Pathogenesis Extracellular matrix 03 medical and health sciences 0302 clinical medicine medicine Humans Inflammation biology Chemistry Amyloidosis Arteries medicine.disease Elastic Tissue Cell biology 030104 developmental biology medicine.anatomical_structure Heart Disease Risk Factors Arterial stiffness biology.protein Elastin 030217 neurology & neurosurgery Elastic fiber Developmental Biology Calcification |
| Zdroj: | Mech Ageing Dev |
| ISSN: | 1872-6216 |
| Popis: | Elastic fibers are the main components of the extracellular matrix of the large arterial wall. Elastic fiber remodeling is an intricate process of synthesis and degradation of the core elastin protein and microfibrils accompanied by the assembly and disassembly of accessory proteins. Age-related morphological, structural, and functional proinflammatory remodeling within the elastic fiber has a profound effect upon the integrity, elasticity, calcification, amyloidosis, and stiffness of the large arterial wall. An age-associated increase in arterial stiffness is a major risk factor for the pathogenesis of diseases of the large arteries such as hypertensive and atherosclerotic vasculopathy. This mini review is an update on the key molecular, cellular, functional, and structural mechanisms of elastic fiber proinflammatory remodeling in large arteries with aging. Targeting structural and functional integrity of the elastic fiber may be an effective approach to impede proinflammatory arterial remodeling with advancing age. |
| Databáze: | OpenAIRE |
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