Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations
| Autor: | Petra H.M. Peeters, Anne Tjønneland, Philippe Autier, Heiner Boeing, Rudolf Kaaks, Pierre Engel, Françoise Clavel-Chapelon, Fränzel J.B. Van Duijnhoven, James McKay, Anja Olsen, Paolo Vineis, Jakob Linseisen, Aurelio Barricarte, Núria Sala, Elio Riboli, Alina Vrieling, Eva Fisher, Sheila Bingham, Antonia Trichopoulou, Tobias Pischon, Erifili Oustoglou, María Dolores Chirlaque, Graham Byrnes, Miren Dorronsoro, Esther Molina, Hendrik B. Bueno-de-Mesquita, Teresa Norat, Nadia Slimani, Marie-Christine Boutron-Ruault, Pietro Ferrari, Paolo Boffetta, Rosario Tumino, Kay-Tee Khaw, Kim Overvad, Giovanna Masala, Eiliv Lund, Timothy J. Key, Andrew W. Roddam, Mazda Jenab, Eugene Jansen, Göran Hallmans, Sabina Rinaldi, Richard Palmqvist, Vardis Dilis, Franco Berrino, Carla H. van Gils, Magritt Brustad, Laudina Rodríguez Suárez, Amalia Mattiello |
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| Přispěvatelé: | Jenab, M., McKay, J., Bueno-De-Mesquita, H.B., Van Duijnhoven, F.J.B., Ferrari, P., Slimani, N., Jansen, E.H.J.M., Pischon, T., Rinaldi, S., Tjønneland, A., Olsen, A., Overvad, K., Boutron-Ruault, M.-C., Clavel-Chapelon, F., Engel, P., Kaaks, R., Linseisen, J., Boeing, H., Fisher, E., Trichopoulou, A., Dilis, V., Oustoglou, E., Berrino, F., Vineis, P., Mattiello, A., Masala, G., Tumino, R., Vrieling, A., Van Gils, C.H., Peeters, P.H., Brustad, M., Lund, E., Chirlaque, M.-D., Barricarte, A., Suárez, L.R., Molina, E., Dorronsoro, M., Sala, N., Hallmans, G., Palmqvist, R., Roddam, A., Key, T.J., Khaw, K.-T., Bingham, S., Boffetta, P., Autier, P., Byrnes, G., Norat, T., Riboli, E. |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Oncology medicine.medical_specialty Genotype Epidemiology Colorectal cancer Population Single-nucleotide polymorphism Calcitriol receptor White People Internal medicine medicine Vitamin D and neurology Humans Genetic Predisposition to Disease Vitamin D education Life Style education.field_of_study Polymorphism Genetic business.industry Case-control study Cancer Middle Aged medicine.disease Vitamin D receptor calcium sensing receptor polymorphisms colorectal cancer European populations European Prospective Investigation into Cancer and Nutrition Calcium Dietary Europe Endocrinology Case-Control Studies Receptors Calcitriol Female Colorectal Neoplasms business Receptors Calcium-Sensing |
| Zdroj: | Jenab, M, McKay, J, Bueno-de-Mesquita, H B, van Duijnhoven, F J B, Ferrari, P, Slimani, N, Jansen, E H J M, Pischon, T, Rinaldi, S, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M-C, Clavel-Chapelon, F, Engel, P, Kaaks, R, Linseisen, J, Boeing, H, Fisher, E, Trichopoulou, A, Dilis, V, Oustoglou, E, Berrino, F, Vineis, P, Mattiello, A, Masala, G, Tumino, R, Vrieling, A, van Gils, C H, Peeters, P H, Brustad, M, Lund, E, Chirlaque, M-D, Barricarte, A, Suárez, L R, Molina, E, Dorronsoro, M, Sala, N, Hallmans, G, Palmqvist, R, Roddam, A, Key, T J, Khaw, K-T, Bingham, S, Boffetta, P, Autier, P, Byrnes, G, Norat, T & Riboli, E 2009, ' Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations ', Cancer Epidemiology, Biomarkers & Prevention, vol. 18, no. 9, pp. 2485-91 . https://doi.org/10.1158/1055-9965.EPI-09-0319 |
| Popis: | Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes may modulate CRC risk independently or by interaction with blood vitamin D concentration and level of dietary calcium intake. A case-control study was conducted nested within the European Prospective Investigation into Cancer and Nutrition. CRC cases (1,248) were identified and matched to 1,248 control subjects. Genotyping for the VDR (BsmI: rs1544410; Fok1: rs2228570) and CASR (rs1801725) genes was done by Taqman, and serum vitamin D (25OHD) concentrations were measured. Conditional logistic regression was used to estimate the incidence rate ratio (RR). Compared with the wild-type bb, the BB genotype of the VDR BsmI polymorphism was associated with a reduced risk of CRC [RR, 0.76; 95% confidence interval (CI), 0.59-0.98). The association was observed for colon cancer (RR, 0.69; 95% CI, 0.45-0.95) but not rectal cancer (RR, 0.97; 95% CI, 0.62-1.49). The Fok1 and CASR genotypes were not associated with CRC risk in this study. No interactions were noted for any of the polymorphisms with serum 25OHD concentration or level of dietary calcium. These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake. (Cancer Epidemiol Biomarkers Prev 2009;18(9):2485-91) |
| Databáze: | OpenAIRE |
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