Modelling protein three-dimensional structure using tritium planigraphy
| Autor: | Vitalii I. Goldanskii, Ludmila A. Baratova, A.V. Shishkov, Grebenshchikov Ni, A.V. Gedrovich, Alexander V. Efimov |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
chemistry.chemical_classification
Globular protein Spatial structure Protein Conformation Hydrolysis Serine Endopeptidases Biophysics Structure (category theory) Fishes A protein Proteins General Medicine Crystallography Protein structure Parvalbumins chemistry Models Chemical X-Ray Diffraction Animals Tritium Amino Acids Biological system Chromatography High Pressure Liquid |
| Zdroj: | European biophysics journal : EBJ. 19(6) |
| ISSN: | 0175-7571 |
| Popis: | We propose the use of data on the topography of the label-accessible surface of a protein molecule obtained by the method of tritium planigraphy as a criterion for choosing the optimal intermediate arrangements of alpha-helices in globular proteins so as to model their three-dimensional structures. This approach has been used for modelling the three-dimensional structure of parvalbumin III from pike. The proposed model has been compared with high-resolution X-ray structural data for a related protein, paryvalbumin from carp. The possibilities and limitations of this approach are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink