Quantification of the early pupillary dilation kinetic to assess rod and cone activity
| Autor: | Christian P. Hamel, Aki Kawasaki, Lorette Leon, Sylvain V. Crippa, Isabelle Meunier, Corinne Kostic |
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| Přispěvatelé: | Salvy-Córdoba, Nathalie, Fondation Asile des aveugles - Hôpital Ophtalmique Jules-Gonin [Lausanne], Université de Lausanne = University of Lausanne (UNIL), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
MESH: Pupil
Male genetic structures Physiology Derivative Reflex Pupillary Pupil 0302 clinical medicine Nuclear magnetic resonance Retinal Rod Photoreceptor Cells Pupillary response MESH: Reflex Pupillary MESH: Middle Aged Multidisciplinary MESH: Kinetics Chemistry Middle Aged MESH: Photic Stimulation Neurology [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs Retinal Cone Photoreceptor Cells Medicine [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female Early phase Adult Melanopsin Science Stimulus (physiology) Kinetic energy Article 03 medical and health sciences Humans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs MESH: Rod Opsins MESH: Retinal Rod Photoreceptor Cells MESH: Humans Rod Opsins MESH: Adult MESH: Male Intensity (physics) Kinetics MESH: Retinal Cone Photoreceptor Cells 030221 ophthalmology & optometry sense organs MESH: Female Biomarkers Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | Scientific reports, vol. 11, no. 1, pp. 9549 Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.9549. ⟨10.1038/s41598-021-88915-z⟩ |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-88915-z⟩ |
| Popis: | Rods, cones and melanopsin contribute in various proportions, depending on the stimulus light, to the pupil light response. This study used a first derivative analysis to focus on the quantification of the dynamics of pupillary dilation that immediately follows light-induced pupilloconstriction in order to identify novel parameters that reflect rod and cone activity. In 18 healthy adults, the pupil response to a 1 s blue light stimulus ranging from − 6.0 to 2.65 log cd/m2 in dark-adapted conditions and to a 1 s blue light stimulus (2.65 log cd/m2) in light-adapted conditions was recorded on a customized pupillometer. Three derivative parameters which describe the 2.75 s following the light onset were quantified: dAMP (maximal amplitude of the positive peak), dLAT (latency of the positive peak), dAUC (area under the curve of the positive peak). We found that dAMP and dAUC but not dLAT have graded responses over a range of light intensities. The maximal positive value of dAMP, representing maximal rate of change of early pupillary dilation phase, occurs at − 1.0 log cd/m2 and this stimulus intensity appears useful for activating rods and cones. From − 0.5 log cd/m2 to brighter intensities dAMP and dAUC progressively decrease, reaching negligible values at 2.65 log cd/m2 indicative of a melanopsin-driven pupil response that masks the contribution from rods and cones to the early phase of pupillary dilation. |
| Databáze: | OpenAIRE |
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