High-carbohydrate, high-fiber diets increase peripheral insulin sensitivity in healthy young and old adults
| Autor: | Geja J. Hageman, Naomi K. Fukagawa, Vernon R. Young, K L Minaker, J W Anderson |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Dietary Fiber Male medicine.medical_specialty Aging medicine.medical_treatment Medicine (miscellaneous) Carbohydrate metabolism Biology chemistry.chemical_compound Internal medicine medicine Dietary Carbohydrates Humans Insulin Pancreatic hormone Triglycerides Aged Aged 80 and over Nutrition and Dietetics Triglyceride Fasting Carbohydrate Glucose clamp technique medicine.disease Hypocholesterolemia Endocrinology Cholesterol Glucose Basal (medicine) chemistry Glucose Clamp Technique Female Energy Intake |
| Zdroj: | The American journal of clinical nutrition. 52(3) |
| ISSN: | 0002-9165 |
| Popis: | To examine extra-alimentary effects of high-carbohydrate, high-fiber (HCF) diets, insulin-mediated glucose disposal employing the euglycemic clamp and hepatic glucose output (HGO) employing [6,6-2H2]glucose were measured in 12 healthy young and old individuals before and after 21-28 d of an HCF diet. Diet lowered fasting concentrations of glucose from 5.3 +/- 0.2 to 5.1 +/- 0.1 mmol/L (p less than 0.01) and insulin from 66.0 +/- 7.9 to 49.5 +/- 5.7 pmol/L (p less than 0.01). Fasting serum cholesterol decreased from 5.17 +/- 0.18 to 3.80 +/- 0.20 mmol/L (p less than 0.01) in young individuals and from 6.15 +/- 0.52 to 4.99 +/- 0.49 mmol/L (p less than 0.01) in elderly individuals. Fasting serum triglyceride concentrations, basal HGO, and insulin suppression of HGO were unchanged by the diet. Glucose disposal rates increased from 18.87 +/- 1.66 before 23.87 +/- 2.78 mumol.kg-1.min-1 after the diet (p less than 0.02). Therefore, HCF diets may improve carbohydrate economy by enhanced peripheral sensitivity to insulin. |
| Databáze: | OpenAIRE |
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