Outbreak of Pseudomonas cepacia Bacteremia in Oncology Patients
| Autor: | Terry A. Argent, Loretta A. Carson, William R. Jarvis, David A. Pegues, Roger L. Anderson, Michael J. Norgard, Charles H. Woernle |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Microbiology (medical) Catheterization Central Venous medicine.medical_specialty medicine.medical_treatment Bacteremia Burkholderia cepacia Ambulatory Care Facilities Disease Outbreaks Cohort Studies Risk Factors Neoplasms Internal medicine Epidemiology Humans Medicine Pseudomonas Infections Blood culture Hematology medicine.diagnostic_test business.industry Outbreak medicine.disease Surgery Catheter Infectious Diseases Female business Central venous catheter Cohort study |
| Zdroj: | Clinical Infectious Diseases. 16:407-411 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/clind/16.3.407 |
| Popis: | In 1991, an outbreak of Pseudomonas cepacia bacteremia (PCB) occurred among patients at an oncology clinic in Alabama. A case-patient was defined as any patient at Alabama Oncology Hematology Associates (AOHA) who had at least one blood culture positive for P. cepacia from 7 August through 31 October. Fourteen case-patients were identified; all required hospitalization (median duration, 17 days), but none died of PCB. A cohort study assessing risk factors for PCB focused on all patients who had been treated on the 8 days when case-patients had last visited AOHA during the period 7-21 August. Only patients with central venous catheters developed PCB (P < .001). Among patients with central venous catheters, PCB occurred only after visits to AOHA at which the catheters were flushed with heparin solution in the AOHA laboratory rather than in the treatment area (P < .001). P. cepacia was cultured from the only intravenous fluid bag used to prepare heparin flush solution in the laboratory during the interval 7-21 August. All outbreak-associated isolates of P. cepacia had an identical DNA ribotype pattern. These findings emphasize the importance of avoiding multiple use of single-use solutions, especially for high-risk patients with long-term indwelling central venous catheters. |
| Databáze: | OpenAIRE |
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