Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation
| Autor: | Robert Marcus, J. I. O. Craig, J Ewing, R S Goodman, Craig J. Taylor, P.A. Dyer, Paul C. Evans, Kay Poulton |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Heterozygote Adolescent Genotype medicine.medical_treatment Graft vs Host Disease Hematopoietic stem cell transplantation Histocompatibility Testing Human leukocyte antigen Cohort Studies Pathogenesis medicine Humans Codon Transplantation Polymorphism Genetic business.industry Siblings Hematopoietic Stem Cell Transplantation Hematology Middle Aged medicine.disease Platelet Endothelial Cell Adhesion Molecule-1 Haematopoiesis surgical procedures operative Graft-versus-host disease Amino Acid Substitution Hematologic Neoplasms Acute Disease Immunology Female business |
| Zdroj: | Bone Marrow Transplantation. 36:151-156 |
| ISSN: | 1476-5365 0268-3369 |
| Popis: | CD31 gene polymorphisms are implicated in the pathogenesis of graft-versus-host disease (GvHD) following haematopoietic stem cell transplantation (HST). We investigated the influence of CD31 genotype on the incidence of GvHD following HST from an human leukocyte antigen (HLA)-identical sibling donor. Donor and recipient CD31 codons 125, 563 and 670 DNA polymorphisms were determined in 85 cases of HLA identical sibling HST from two transplant centres. A correlation between CD31 genotype and acute GvHD was considered significant if observed in patients from both transplant centres independently. A strong correlation was identified between donor CD31 codon 125 genotype and the incidence of acute GvHD. Acute GvHD grades II-IV occurred in 27 of 46 (59%) recipients with a CD31 codon 125 leucine / valine heterozygous donor compared to nine of 39 (23%) recipients with a CD31 codon 125 homozygous donor (P=0.0019, relative-risk 2.45, 95% confidence interval 1.3-4.5). This correlation was significant in patients from both transplant centres (P=0.015 and P=0.019). We suggest that CD31 genotype may influence the function of donor-derived leukocytes and may be informative when there is a choice of comparable donors. |
| Databáze: | OpenAIRE |
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