High SARS-CoV-2 IgG/IGM seroprevalence in asymptomatic Congolese in Brazzaville, the Republic of Congo
| Autor: | Line Lobaloba Ingoba, Francine Ntoumi, Claujens Chastel Mfoutou Mapanguy, Kamal Rauchelvy Boumpoutou, Jeannhey Christevy Vouvoungui, Matthieu Ndounga, Armel Landry Batchi-Bouyou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty IgM IgG 030106 microbiology Population Infectious and parasitic diseases RC109-216 Asymptomatic Immunoglobulin G Article Serology COVID-19 Serological Testing 03 medical and health sciences The Republic of the Congo 0302 clinical medicine Seroepidemiologic Studies Internal medicine Seroprevalence Medicine Humans Adults 030212 general & internal medicine education education.field_of_study biology business.industry SARS-CoV-2 Incidence (epidemiology) COVID-19 General Medicine Middle Aged Infectious Diseases Congo Immunoglobulin M Asymptomatic Diseases biology.protein Female medicine.symptom business |
| Zdroj: | International Journal of Infectious Diseases, Vol 106, Iss, Pp 3-7 (2021) International Journal of Infectious Diseases |
| ISSN: | 1201-9712 |
| Popis: | Highlights • COVID-19 infection from April to July 2020 in Brazzaville. • Seroprevalence using two rapid diagnostic tests. • IgG and IgM seroprevalence higher in Congolese women. • 7.4% of RT-PCR positive asymptomatic Congolese adults. • 15% of seroconverted Congolese adults. Abstract Introduction The republic of the Congo faced its first COVID-19 case on 14 March 2020, and some weeks later initiated individual and country protective measures that are still applied in July, 2020. Along the course of time, the progression of clinical cases appears to be lower than expected based on RT-PCR testing which was quite limited. In order to evaluate the incidence of SARS-CoV-2 within the population, a seroprevalence study was conducted on healthy individuals from different districts of Brazzaville willing to know their infectious status with regard to COVID-19. Methods We collected oropharyngeal swab and blood samples from 754 healthy volunteers for screening between April and July, 2020. Samples were analyzed for SARS-CoV-2 using a qualitative reverse transcription polymerase chain reaction (RT-PCR) assay and Immunoglo bulin G and M were detected using using two different rapid diagnostic tests. Results Out of 754 samples, 56 were found to have active SARS-COV2 infection (7.4%). This means 92.5% (n = 698/754) were RT-PCR negative out of which 117 had detectable anti-SARS-CoV-2 antibodies in their serum. Among these RT-PCR negative subjects, the seroprevalence raised from 1.7% for IgG + and 2.5% for IgM + in April to 14.2% of IgG and 17.6% of IgM in July. No difference was found according to the district of residence (P = 0.108). With regard to gender, 5% of women against 0% of men had either IgG and IgM in April. During the first three months, seroprevalence was significantly higher in women within IgG (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|