Gliadin induced oxidative stress and altered cellular responses in human intestinal cells: An in‐vitro study to understand the cross‐talk between the transcription factor Nrf‐2 and multifunctional APE1 enzyme

Autor:	Kunj Bihari Gupta, Monisha Dhiman, Anil Kumar Mantha
Rok vydání:	2022
Předmět:	Curcumin DNA Repair NF-E2-Related Factor 2 Health Toxicology and Mutagenesis General Medicine Endonucleases Toxicology Multifunctional Enzymes Biochemistry Gliadin Oxidative Stress DNA-(Apurinic or Apyrimidinic Site) Lyase Humans Molecular Medicine Molecular Biology Transcription Factors
Zdroj:	Journal of Biochemical and Molecular Toxicology. 36
ISSN:	1099-0461 1095-6670
DOI:	10.1002/jbt.23096
Popis:	The present study examined the wheat protein gliadin-induced oxidative and nitrosative stress and its downstream responses in human intestinal HCT-116 and HT-29 cells. The beneficial role of dietary phytochemical curcumin and role of multifunctional enzyme Apurinic/aprymidinic endonuclease 1 (APE1) a major player involved in the base excision repair (BER)-pathway in gliadin intolerant intestinal HCT-116 and HT-29 cell lines were evaluated as an in vitro model study. The cultured cells were exposed to gliadin protein, H
Databáze:	OpenAIRE
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