Two cases of hypertrophic pachymeningitis associated with myeloperoxidase antineutrophil cytoplasmic autoantibody (MPO-ANCA)-positive pulmonary silicosis in tunnel workers
| Autor: | Hiroyo Kourakata, Syoji Miyamura, Takako Saeki, Nobuya Fujita, Hajime Yamazaki |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Pathology medicine.medical_specialty Silicosis urologic and male genital diseases Antibodies Antineutrophil Cytoplasmic Rheumatology immune system diseases Occupational Exposure Internal medicine Humans Medicine Meningitis cardiovascular diseases skin and connective tissue diseases Glucocorticoids Peroxidase biology business.industry Autoantibody Glomerulonephritis Hypertrophy General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging respiratory tract diseases Occupational Diseases Titer Myeloperoxidase biology.protein Antibody business Vasculitis |
| Zdroj: | Clinical Rheumatology. 23:76-80 |
| ISSN: | 1434-9949 0770-3198 |
| DOI: | 10.1007/s10067-003-0815-1 |
| Popis: | Two cases of hypertrophic pachymeningitis (HP) associated with pulmonary silicosis in tunnel workers are described. In both cases the myeloperoxidase antineutrophil cytoplasmic autoantibody (MPO-ANCA) was positive. Two patients with pulmonary silicosis developed headache and neurological disturbance, and a diagnosis of HP was made. In both cases the serum CRP level and the MPO-ANCA titer were elevated. Corticosteroid therapy produced a rapid improvement in all the clinical and laboratory parameters. Although an association has been noted between exposure to silica dust and ANCA-associated vasculitis, particularly glomerulonephritis, central nervous system involvement is rare. However, there have been some recent reports of HP cases that were positive for ANCA, and the association between HP and vasculitis has been discussed in the medical literature. HP may be one feature of multiorgan involvement in ANCA-associated disease, and the association between silica dust exposure and HP should be considered, as with other forms of ANCA-associated vasculitis. |
| Databáze: | OpenAIRE |
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