Five-year outcomes of sirolimus-eluting versus paclitaxel-eluting stents: A propensity matched study: Clinical evidence of late catch-up?
| Autor: | Young Guk Ko, Donghoon Choi, Joo Young Yang, Yangsoo Jang, Byoung Kwon Lee, Hyuck Moon Kwon, Jung Sun Kim, Dong Wun Jeon, Young Won Yoon, Bum-Kee Hong, Myeong Ki Hong, Byeong Keuk Kim, Pil-Ki Min, Sung Jin Oh |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Paclitaxel medicine.medical_treatment Coronary Artery Disease Coronary artery disease Restenosis Internal medicine medicine Clinical endpoint Humans Registries Myocardial infarction Propensity Score Aged Sirolimus business.industry Hazard ratio Stent Drug-Eluting Stents Middle Aged medicine.disease Treatment Outcome Drug-eluting stent Propensity score matching Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | International Journal of Cardiology. 152:302-306 |
| ISSN: | 0167-5273 |
| Popis: | Background Siroliums-eluting stents (SES) and paclitaxel-eluting stents (PES) have been widely used for the treatment of coronary artery disease. We investigated 5-year clinical outcomes of patients treated with SES versus PES in a multicenter registry. Methods We used a propensity score matching method with 2:1 matching, including 512 patients treated with SES and 256 patients treated with PES from March 2003 to December 2004. The primary endpoint was major adverse cardiac events, which included all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR). Results After matching, baseline characteristics were similar between the two groups. At 5years, cumulative survival free of major adverse cardiac events, MI, and stent thrombosis did not differ between the two groups. Survival free of TVR at 5years was higher in the SES group (88.4%) than the PES group (84.3%, Log-rank p =0.016). In contrast to the trend toward more likely target lesion revascularization in the PES group during the first 2years (hazard ratio 0.62, p =0.057), target lesion revascularization tended to occur more frequently in the SES group from 2 to 5years (hazard ratio 2.26, p =0.099). Conclusions Long-term risk of TVR was slightly lower with SES, compared with PES, despite no significant difference in major adverse cardiac events. However, the SES group had more frequent target lesion reintervention 2 to 5years after stent implantation, whereas reintervention in the PES group occurred mainly within the first 2years. This may reflect the temporal difference in neointimal growth of the two stent types. |
| Databáze: | OpenAIRE |
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