Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy
| Autor: | Bosede B Afolabi, Opeyemi Abayomi Obilade, Alani Suleimon Akanmu, Fiona Broughton Pipkin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Physiology
Thromboxane Maternal Health lcsh:Medicine Blood Pressure Prostacyclin 030204 cardiovascular system & hematology Biochemistry Thromboxane A2 chemistry.chemical_compound 0302 clinical medicine Pregnancy Medicine and Health Sciences Lipid Hormones Longitudinal Studies lcsh:Science reproductive and urinary physiology 030219 obstetrics & reproductive medicine Multidisciplinary Pregnancy Outcome Obstetrics and Gynecology Thromboxanes Neurochemistry Hematology Genetic Diseases Creatinine Gestation Female Neurochemicals Research Article Glomerular Filtration Rate medicine.drug Adult medicine.medical_specialty Genotype Renal function 6-Ketoprostaglandin F1 alpha Anemia Sickle Cell Preeclampsia Young Adult 03 medical and health sciences Autosomal Recessive Diseases Internal medicine medicine Humans Clinical Genetics Renal Physiology Sickle Cell Disease business.industry lcsh:R Biology and Life Sciences medicine.disease Epoprostenol Hormones Hemoglobinopathies Pregnancy Complications Thromboxane B2 Cross-Sectional Studies Endocrinology chemistry Women's Health Eicosanoids lcsh:Q business Biomarkers Neuroscience |
| Zdroj: | PLoS ONE, Vol 12, Iss 9, p e0184345 (2017) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Pregnancy increases the risk of morbidity and mortality in sickle cell disease. We previously showed pregnant women with sickle cell disease to have a relatively low plasma renin concentration in late pregnancy, associated with a lack of the expected plasma volume expansion. We hypothesized this to be due to increased systemic vascular resistance through an imbalance between the vasodilator prostacyclin and vasoconstrictor thromboxane, associated with decreased glomerular filtration rate (GFR). Objective To compare estimated prostacyclin, thromboxane and GFR in non-pregnant and pregnant women with hemoglobin SS (HbSS) and AA (HbAA). Study design Four groups of 20 normotensive, nulliparous women were studied in Lagos, Nigeria: pregnant HbSS or HbAA women at 36–40 weeks gestation; non-pregnant HbSS and HbAA controls. We measured stable metabolites of prostacyclin and thromboxane A2 by enzyme-linked immunosorbent assay; GFR using the Cockcroft-Gault equation. Data analysis was by independent (Student’s) t-test or Mann-Whitney U test for comparisons between any two groups of continuous variables, univariate ANOVA for multiple groups and Pearson’s correlation coefficient for degree of association between variables. Results HbSS women had lower serum 6-keto-PGF1α concentrations than HbAA, whether pregnant or non-pregnant (P |
| Databáze: | OpenAIRE |
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