A comparably high virulence strain of porcine reproductive and respiratory syndrome virus isolated in Taiwan
Autor: | Yi-Han Lee, Min-Yuan Chia, Wei-Cheng Lee, Fu-Hsiang Hou, Jiunn-Wang Liao |
---|---|
Rok vydání: | 2018 |
Předmět: |
Male
Farms 040301 veterinary sciences Swine viruses animal diseases 030231 tropical medicine Immunology Porcine Reproductive and Respiratory Syndrome Taiwan Virulence Viremia Biology Microbiology Severity of Illness Index Virus 0403 veterinary science 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Animals Porcine respiratory and reproductive syndrome virus Phylogeny General Veterinary Strain (biology) Mortality rate virus diseases 04 agricultural and veterinary sciences General Medicine respiratory system medicine.disease Porcine reproductive and respiratory syndrome virus biology.organism_classification Virology Titer Disease Models Animal Infectious Diseases Pneumonia (non-human) |
Zdroj: | Comparative immunology, microbiology and infectious diseases. 65 |
ISSN: | 1878-1667 |
Popis: | Porcine reproductive and respiratory syndrome virus (PRRSV) has been endemic in Taiwan since 1991. This study aimed to present a highly virulent PRRSV in Taiwan based on farm data collection and both in vitro and in vivo evaluations in virus challenge studies. This virulent PRRSV strain was first noticed on Farm TSYM due to continuously high nursery mortality rate and severe PRRSV-associated pneumonia. In phylogenetic surveillance, the PRRSV TSYM-strain remained in the predominant position for years, even with several other PRRSV strain invasions. In laboratory challenge trials, the TSYM-strain led to prolonged pyrexia, growth retardation, high mortality rates and high viremia titer that similar to the highly pathogenic PRRSV. The TSYM-strain isolate also triggered early interleukin-10 up-regulation and significantly higher infection rates under in vitro experiments. This study provides information of a comparably virulent strain in Taiwan and its appearance in both farm and laboratory levels. |
Databáze: | OpenAIRE |
Externí odkaz: |