Relationship between Insulin-Like Growth Factor Type 1 and Intrauterine Growth
| Autor: | Vesna Bokan-Mirković, Tamara Gojkovic, Lidija Banjac, Gorica Banjac, Jelena Kotur-Stevuljevic, Goran Banjac |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
030213 general clinical medicine 0209 industrial biotechnology Percentile Birth weight medicine.medical_treatment Physiology lcsh:Medicine Gestational Age 02 engineering and technology Infant newborn Fetal growth retardation 03 medical and health sciences Insulin-like growth factor 020901 industrial engineering & automation 0302 clinical medicine medicine Birth Weight Humans Original Scientific Papers Fetus business.industry Significant difference lcsh:R Gestational age Insulin-like growth factor I General Medicine Cross-sectional studies Infant newborn Quantitative determination 3. Good health Novorođenče Inzulinu sličan faktor rasta I Fetusni rast retardacija Presječna istraživanja Female business |
| Zdroj: | Acta Clinica Croatica, Vol 59, Iss 1., Pp 91-96 (2020) Acta Clinica Croatica Acta clinica Croatica Volume 59. Issue 1. |
| ISSN: | 1333-9451 0353-9466 |
| Popis: | Insulin-like growth factor 1 (IGF-1) is a regulator of intrauterine growth, and circulating concentrations are reduced in intrauterine growth-restricted fetuses. The aim of our study was to investigate the relationship between IGF-1 levels in newborns and intrauterine growth, expressed as birth weight (BW). The research was designed as a cross-sectional study. The study included 71 premature newborns, gestational age (GA) ≤33 weeks. Quantitative determination of IGF-1 was performed in the 33rd post-menstrual week (pmw) to make the measurements more comparable. We used an enzyme-bound immunosorbent test for quantitative determination of IGF-1. Our results showed the mean IGF-1 level in premature newborns in 33rd pmw to be 23.1±4.56 (range 15.44-39.75) μg/L. There was no difference in IGF-1 values between male (23.1±4.98 μg/L) and female (23.1±4.87 μg/L) newborns. Tere was no significant difference in the average IGF-1 levels between male and female newborns with BW 50th percentile for GA either (p>0.50). Only BW Inzulinu sličan faktor rasta (IGF-1) je jedan od čimbenika koji utječu na intrauterini rast. Serumske razine IGF-1 su smanjene u fetusima s intrauterinim zastojem rasta. Cilj našega istraživanja bio je ispitati odnos između razine IGF-1 u nedonoščadi i intrauterinog rasta izraženog kao porođajna težina (PT). Istraživanje je provedeno kao presječna studija. U studiju je bilo uključeno 71 nedonošče gestacijske dobi (GD) ≤33 tjedna. Kvantitativno određivanje IGF-1 provedeno je u 33. postmenstruacijskom tjednu (pmt) radi bolje usporedivosti rezultata. Za kvantitativno određivanje IGF-1 rabili smo enzimski imunosorbentni test. Naši rezultati pokazali su da je srednja razina IGF-1 u nedonoščadi u 33. pmt iznosila 23,1±4,56 (raspon 15,44-39,75) μg/L. Nije bilo razlike u vrijednostima IGF-1 između muške (23,1±4,98 μg/L) i ženske (23,1±4,87 μg/L) nedonoščadi. Također nije bilo značajne razlike u srednjim razinama IGF-1 između nedonoščadi s PT 50. percentila za GD (p>0,50). Nedonoščad s niskom PT ( |
| Databáze: | OpenAIRE |
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