Assessment of serum sialic acid correlated with C3 in children with Mycoplasma pneumoniae pneumonia

Autor: Zhimin Chen, Li Zhang, Chun‐Zhen Hua, Xiao‐Fang Wang, Yu-Mei Mi, Qi Qi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Microbiology (medical)
Male
medicine.medical_specialty
Mycoplasma pneumoniae
Adolescent
Clinical Biochemistry
medicine.disease_cause
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
children
Internal medicine
Pneumonia
Mycoplasma
medicine
Immunology and Allergy
pneumonia
Humans
C3
Child
Mycoplasma pneumoniae pneumonia
Research Articles
business.industry
Biochemistry (medical)
Public Health
Environmental and Occupational Health
Infant
Complement C4
Hematology
Complement C3
medicine.disease
Recovery stage
Acute stage
N-Acetylneuraminic Acid
Sialic acid
Medical Laboratory Technology
Pneumonia
030104 developmental biology
C-Reactive Protein
chemistry
sialic acid
030220 oncology & carcinogenesis
Case-Control Studies
Child
Preschool
Immunoglobulin G
Female
business
Research Article
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
0887-8013
Popis: Background Different from the diagnosis of bacterial infections, Mycoplasma pneumoniae pneumonia (MPP) is still lacking of convenient non‐specific laboratory parameters. Method A total of 125 children with MPP were included in the MPP group and 89 children with Mycoplasma‐negative pneumonia were included in the control group, and the sera were collected from the children at both the acute and recovery stages in the two groups. Results The sialic acid and C3 in the MPP group were significantly higher than those in the control group both at the acute and at the recovery stage. On the other hand, the sialic acid and C3 at the acute stage were significantly higher than those at the recovery stage in the MPP group. However, in the control group, the sialic acid and C3 demonstrated IgG exhibited no significant change between the acute stage and the recovery stage. Lastly, positive correlations between sialic acid level and C3 level were identified in the MPP group at both acute and recovery stages. Conclusion Our study demonstrated that the serum sialic acid correlated with C3 specifically increased in children with MPP, indicating that it might be the important non‐specific parameters in the diagnosis of MPP.
Databáze: OpenAIRE
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