Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments
| Autor: | Zoltán Bozóki, Fruzsina Kun-Szabó, Rita Ambrus, Béla Hopp, Tamás Smausz, Tibor Ajtai, Judit Kopniczky, Attila Andrásik, Eszter Nagy, Piroska Szabó-Révész |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Scanning electron microscope General Chemical Engineering Analytical chemistry 02 engineering and technology 030226 pharmacology & pharmacy Article law.invention lcsh:Chemistry Micrometre 03 medical and health sciences symbols.namesake 0302 clinical medicine law Scanning mobility particle sizer General Materials Science Dissolution Laser ablation preformulation particle size nanoparticle(s) 021001 nanoscience & nanotechnology Laser poorly water-soluble drug(s) lcsh:QD1-999 symbols Particle size nanosphere(s) 0210 nano-technology Raman spectroscopy |
| Zdroj: | Nanomaterials Volume 11 Issue 4 Nanomaterials, Vol 11, Iss 996, p 996 (2021) |
| ISSN: | 2079-4991 |
| DOI: | 10.3390/nano11040996 |
| Popis: | In pharmaceutical development, more and more drugs are classified as poorly water-soluble or insoluble. Particle size reduction is a common way to fight this trend by improving dissolution rate, transport characteristics and bioavailability. Pulsed laser ablation is a ground-breaking technique of drug particle generation in the nano- and micrometer size range. Meloxicam, a commonly used nonsteroidal anti-inflammatory drug with poor water solubility, was chosen as the model drug. The pastille pressed meloxicam targets were irradiated by a Ti:sapphire laser (τ = 135 fs, λc = 800 nm) in air and in distilled water. Fourier transform infrared and Raman spectroscopies were used for chemical characterization and scanning electron microscopy to determine morphology and size. Additional particle size studies were performed using a scanning mobility particle sizer. Our experiments demonstrated that significant particle size reduction can be achieved with laser ablation both in air and in distilled water without any chemical change of meloxicam. The size of the ablated particles (~50 nm to a few microns) is approximately at least one-tenth of the size (~10–50 micron) of commercially available meloxicam crystals. Furthermore, nanoaggregate formation was described during pulsed laser ablation in air, which was scarcely studied for drug/organic molecules before. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|