Mesodermal and Hematopoietic Differentiation from ES and iPS Cells
| Autor: | Kenzaburo Tani, Daisuke Sugiyama, Tomoko Inoue-Yokoo |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
medicine.medical_specialty Hematology Cellular differentiation Induced Pluripotent Stem Cells Cell Differentiation Cell Biology Biology Hematopoietic Stem Cells Embryonic stem cell Regenerative medicine Cell biology Mesoderm Transplantation Haematopoiesis Internal medicine Immunology medicine Animals Humans Stem cell Induced pluripotent stem cell Embryonic Stem Cells |
| Zdroj: | Stem Cell Reviews and Reports. 9:422-434 |
| ISSN: | 1558-6804 1550-8943 |
| DOI: | 10.1007/s12015-012-9388-1 |
| Popis: | Embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any type of tissue when grown in a suitable culture environment and are considered valuable tools for regenerative medicine. In the field of hematology, generation of hematopoietic stem cells (HSCs) and mature hematopoietic cells (HCs) from ES and iPS cells through mesodermal cells, the ancestors of HCs, can facilitate transplantation and transfusion therapy. Several studies report generation of functional HCs from both mouse and human ES and iPS cells. This approach will likely be applied to individual patient-derived iPS cells for regenerative medicine approaches and drug screening in the future. Here, we summarize current studies of HC-generation from ES and iPS cells. |
| Databáze: | OpenAIRE |
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