Placental insufficiency in fetuses that slow in growth but are born appropriate for gestational age: a prospective longitudinal study

Autor: Nadia Bardien, Clare Whitehead, Susan P. Walker, Stephen Tong, Antony Ugoni, Susan McDonald
Rok vydání: 2022
Předmět:
Male
lcsh:Medicine
Fetal Distress
Umbilical Arteries
Fetal Development
0302 clinical medicine
Pregnancy
Fetal distress
Birth Weight
Single-Blind Method
Prospective Studies
030212 general & internal medicine
Prospective cohort study
lcsh:Science
reproductive and urinary physiology
Uncategorized
Fetal Growth Retardation
030219 obstetrics & reproductive medicine
Multidisciplinary
Obstetrics
Pregnancy Outcome
Brain
Gestational age
Stillbirth
3. Good health
Cohort
Female
Research Article
Adult
Risk
medicine.medical_specialty
Birth weight
Embryonic Development
Gestational Age
Placental insufficiency
Ultrasonography
Prenatal
Young Adult
03 medical and health sciences
medicine
Humans
Gynecology
Fetus
Cesarean Section
business.industry
lcsh:R
Infant
Newborn
Ultrasonography
Doppler
Delivery
Obstetric
Placental Insufficiency
medicine.disease
lcsh:Q
business
Follow-Up Studies
Zdroj: PLoS ONE, Vol 11, Iss 1, p e0142788 (2016)
PLoS ONE
DOI: 10.26181/21747812
Popis: Objectives: To determine whether fetuses that slow in growth but are then born appropriate for gestational age (AGA, birthweight >10th centile) demonstrate ultrasound and clinical evidence of placental insufficiency. Methods: Prospective longitudinal study of 48 pregnancies reaching term and a birthweight >10th centile. We estimated fetal weight by ultrasound at 28 and 36 weeks, and recorded birthweight to determine the relative change in customised weight across two timepoints: 28-36 weeks and 28 weeks-birth. The relative change in weight centiles were correlated with fetoplacental Doppler findings performed at 36 weeks. We also examined whether a decline in growth trajectory in fetuses born AGA was associated with operative deliveries performed for suspected intrapartum compromise. Results: The middle cerebral artery pulsatility index (MCA-PI) showed a linear association with fetal growth trajectory. Lower MCA-PI readings (reflecting greater diversion of blood supply to the brain) were significantly associated with a decline in fetal growth, both between 28-36 weeks (p = 0.02), and 28 weeks-birth (p = 0.0002). The MCA-PI at 36 weeks was significantly higher among those with a relative weight centile fall 30% (mean MCA-PI 1.94 vs 1.56; p
Databáze: OpenAIRE
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