The effect of total lymphoid irradiation and low-dose steroids on T lymphocyte populations in multiple sclerosis: correlation with clinical and MRI status
| Autor: | Corinne Devereux, P. Dowling, George Zito, Raymond Troiano, James M. Oleske, Christine Rohowsky-Kochan, Leo J. Wolansky, S. Bansil, Donna Molinaro, Thomas N. Denny, Stuart D. Cook, A. Jotkowitz |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Multiple Sclerosis Lymphocyte CD3 T-Lymphocytes Population Natural killer cell Immunophenotyping Placebos Double-Blind Method T-Lymphocyte Subsets Internal medicine medicine Cytotoxic T cell Humans Lymphocyte Count education Glucocorticoids education.field_of_study biology business.industry T lymphocyte Magnetic Resonance Imaging medicine.anatomical_structure Endocrinology Neurology biology.protein Prednisone Female Neurology (clinical) business CD8 Whole-Body Irradiation |
| Zdroj: | Journal of the neurological sciences. 152(2) |
| ISSN: | 0022-510X |
| Popis: | We have monitored the cell surface phenotypic changes occurring in T, B and NK cells of chronic progressive multiple sclerosis (MS) patients after total lymphoid irradiation (TLI) plus low-dose prednisone (TLI-LDP) therapy in comparison to sham TLI-LDP. TLI-LDP resulted in a marked reduction in the relative and absolute number of total CD3+ T cells, CD4+ helper T cells, CD4+ CD45RA+ naive T cells and CD19+ B cells for at least 1 year after treatment. No change occurred in the percent CD8+ T cells although the number of these cells declined after radiotherapy. The CD4/CD8 T cell ratio was also decreased. The relative percent of CD16+ NK cells increased steadily after TLI-LDP while the number of NK cells transiently declined but returned to baseline values 1 year later. An increase in the percent of CD2+ CD3- cells and a decrease in their number after therapy was also observed. In contrast, no significant changes in the number of T, B or NK cells were seen in the MS patients receiving sham TLI-LDP. These results provide further evidence that radiotherapy causes a reduction of immunocompetent T and B cells and that a population of possibly NK cells and/or immature T cells appears to be repopulating the circulation after TLI. In addition, a correlation was observed between alterations in lymphocyte populations and the presence or absence of contrast enhancing or new T2 lesions on brain magnetic resonance imaging (MRI) in the TLI-LDP treated MS patients. Patients devoid of contrast enhancing or new T2 lesions had a decreased percentage of CD3+ and CD4+ T cells prior to therapy and at six months following TLI-LDP compared to patients with such lesions. An association was also observed between stability in disease activity as determined on the Expanded Disability Status Scale and relative values of CD3 T cells. |
| Databáze: | OpenAIRE |
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