Human cellular restriction factors that target HIV-1 replication

Autor: Jeremy Luban, Kuan-Teh Jeang, Klaus Strebel
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Cyclophilin A/physiology
Ubiquitin-Protein Ligases
Virus Replication/*immunology
lcsh:Medicine
HIV Infections
APOBEC-3G Deaminase
Carrier Proteins/physiology
Biology
GPI-Linked Proteins
Virus Replication
Membrane Glycoproteins/physiology
Antiviral Restriction Factors
Tripartite Motif Proteins
03 medical and health sciences
Cyclophilin A
Antigens
CD
Cytidine Deaminase
Antigens
CD/physiology
microRNA
Humans
MicroRNAs/physiology
HIV-1/*immunology
APOBEC3G
Cytidine Deaminase/physiology
030304 developmental biology
Medicine(all)
ddc:616
Genetics
0303 health sciences
Membrane Glycoproteins
030302 biochemistry & molecular biology
lcsh:R
HIV Infections/*immunology/virology
General Medicine
Cytidine deaminase
Immunity
Innate
MicroRNAs
Viral replication
HIV-1
Tetherin
Minireview
Carrier Proteins
Intracellular
Zdroj: BMC Medicine, Vol 7, Iss 1, p 48 (2009)
BMC medicine
BMC Medicine
BMC Medicine, Vol. 7 (2009) P. 48
ISSN: 1741-7015
Popis: Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5α), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.
Databáze: OpenAIRE
Externí odkaz: