Glycerophosphocholine Metabolites and Cardiovascular Disease Risk Factors in Adolescents
| Autor: | Graeme P. Taylor, Suzanne Veillette, Michal Abrahamowicz, Lisa J. Strug, Michel Perron, Hongbin Xu, Daniel Gaudet, Simon Czajkowski, Zdenka Pausova, Catriona Syme, Tomáš Paus, Gabriel Leonard, Yun Wang, Jean Shin, Steffany A. L. Bennett, Louis Richer |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Adolescent Disease Cohort Studies 03 medical and health sciences Risk Factors Physiology (medical) Internal medicine medicine Humans Child business.industry Lipid metabolism medicine.disease Obesity 030104 developmental biology Endocrinology Cardiovascular Diseases Glycerophosphates Disease risk Female Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | Circulation. 134:1629-1636 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circulationaha.116.022993 |
| Popis: | Background: Glycerophosphocholine (GPC) metabolites modulate atherosclerosis and thus risk for cardiovascular disease (CVD). Preclinical CVD may start during adolescence. Here, we used targeted serum lipidomics to identify a new panel of GPCs, and tested whether any of these GPCs are associated, in adolescence, with classical risk factors of CVD, namely excess visceral fat (VF), elevated blood pressure, insulin resistance, and atherogenic dyslipidemia. Methods: We studied a population-based sample of 990 adolescents (12–18 years, 48% male), as part of the Saguenay Youth Study. Using liquid chromatography-electrospray ionization-mass spectrometry, we identified 69 serum GPCs within the 450 to 680 m / z range. We measured VF with MRI. Results: We identified several novel GPCs that were associated with multiple CVD risk factors. Most significantly, PC16:0/2:0 was negatively associated with VF ( P =1.4×10 –19 ), blood pressure ( P =7.7×10 –5 ), and fasting triacylglycerols ( P =9.0×10 –5 ), and PC14:1/0:0 was positively associated with VF ( P =3.0×10 –7 ), fasting insulin ( P =5.4×10 –32 ), and triacylglycerols ( P =1.4×10 –29 ). The Sobel test of mediation revealed that both GPCs mediated their respective relations between VF (as a potential primary exposure) and CVD risk factors (as outcomes, P values–3 ). Furthermore, a GPC shown recently to predict incident coronary heart disease in older adults, PC18:2/0:0, was associated with several CVD risk factors in adolescents; these associations were less strong than those with the newly identified GPCs. Conclusions: We identified novel GPCs strongly associated with multiple CVD risk factors in adolescents. These GPCs may be sensitive indicators of obesity-related risk for CVD outcomes in adults, and may improve biological understanding of CVD risk. |
| Databáze: | OpenAIRE |
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